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Phenotype of normal spirometry in an aging population.

Publication ,  Journal Article
Vaz Fragoso, CA; McAvay, G; Van Ness, PH; Casaburi, R; Jensen, RL; MacIntyre, N; Gill, TM; Yaggi, HK; Concato, J
Published in: Am J Respir Crit Care Med
October 1, 2015

RATIONALE: In aging populations, the commonly used Global Initiative for Chronic Obstructive Lung Disease (GOLD) may misclassify normal spirometry as respiratory impairment (airflow obstruction and restrictive pattern), including the presumption of respiratory disease (chronic obstructive pulmonary disease [COPD]). OBJECTIVES: To evaluate the phenotype of normal spirometry as defined by a new approach from the Global Lung Initiative (GLI), overall and across GOLD spirometric categories. METHODS: Using data from COPDGene (n = 10,131; ages 45-81; smoking history, ≥10 pack-years), we evaluated spirometry and multiple phenotypes, including dyspnea severity (Modified Medical Research Council grade 0-4), health-related quality of life (St. George's Respiratory Questionnaire total score), 6-minute-walk distance, bronchodilator reversibility (FEV1 % change), computed tomography-measured percentage of lung with emphysema (% emphysema) and gas trapping (% gas trapping), and small airway dimensions (square root of the wall area for a standardized airway with an internal perimeter of 10 mm). MEASUREMENTS AND MAIN RESULTS: Among 5,100 participants with GLI-defined normal spirometry, GOLD identified respiratory impairment in 1,146 (22.5%), including a restrictive pattern in 464 (9.1%), mild COPD in 380 (7.5%), moderate COPD in 302 (5.9%), and severe COPD in none. Overall, the phenotype of GLI-defined normal spirometry included normal adjusted mean values for dyspnea grade (0.8), St. George's Respiratory Questionnaire (15.9), 6-minute-walk distance (1,424 ft [434 m]), bronchodilator reversibility (2.7%), % emphysema (0.9%), % gas trapping (10.7%), and square root of the wall area for a standardized airway with an internal perimeter of 10 mm (3.65 mm); corresponding 95% confidence intervals were similarly normal. These phenotypes remained normal for GLI-defined normal spirometry across GOLD spirometric categories. CONCLUSIONS: GLI-defined normal spirometry, even when classified as respiratory impairment by GOLD, included adjusted mean values in the normal range for multiple phenotypes. These results suggest that among adults with GLI-defined normal spirometry, GOLD may misclassify normal phenotypes as having respiratory impairment.

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Published In

Am J Respir Crit Care Med

DOI

EISSN

1535-4970

Publication Date

October 1, 2015

Volume

192

Issue

7

Start / End Page

817 / 825

Location

United States

Related Subject Headings

  • Spirometry
  • Respiratory System
  • Quality of Life
  • Pulmonary Emphysema
  • Pulmonary Disease, Chronic Obstructive
  • Phenotype
  • Models, Statistical
  • Middle Aged
  • Male
  • Humans
 

Citation

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ICMJE
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Vaz Fragoso, C. A., McAvay, G., Van Ness, P. H., Casaburi, R., Jensen, R. L., MacIntyre, N., … Concato, J. (2015). Phenotype of normal spirometry in an aging population. Am J Respir Crit Care Med, 192(7), 817–825. https://doi.org/10.1164/rccm.201503-0463OC
Vaz Fragoso, Carlos A., Gail McAvay, Peter H. Van Ness, Richard Casaburi, Robert L. Jensen, Neil MacIntyre, Thomas M. Gill, H Klar Yaggi, and John Concato. “Phenotype of normal spirometry in an aging population.Am J Respir Crit Care Med 192, no. 7 (October 1, 2015): 817–25. https://doi.org/10.1164/rccm.201503-0463OC.
Vaz Fragoso CA, McAvay G, Van Ness PH, Casaburi R, Jensen RL, MacIntyre N, et al. Phenotype of normal spirometry in an aging population. Am J Respir Crit Care Med. 2015 Oct 1;192(7):817–25.
Vaz Fragoso, Carlos A., et al. “Phenotype of normal spirometry in an aging population.Am J Respir Crit Care Med, vol. 192, no. 7, Oct. 2015, pp. 817–25. Pubmed, doi:10.1164/rccm.201503-0463OC.
Vaz Fragoso CA, McAvay G, Van Ness PH, Casaburi R, Jensen RL, MacIntyre N, Gill TM, Yaggi HK, Concato J. Phenotype of normal spirometry in an aging population. Am J Respir Crit Care Med. 2015 Oct 1;192(7):817–825.

Published In

Am J Respir Crit Care Med

DOI

EISSN

1535-4970

Publication Date

October 1, 2015

Volume

192

Issue

7

Start / End Page

817 / 825

Location

United States

Related Subject Headings

  • Spirometry
  • Respiratory System
  • Quality of Life
  • Pulmonary Emphysema
  • Pulmonary Disease, Chronic Obstructive
  • Phenotype
  • Models, Statistical
  • Middle Aged
  • Male
  • Humans