Inhibition of hepatic phosphatidylcholine synthesis by malathion in rats.

Journal Article (Journal Article)

Rats maintained on a 20% casein diet were given malathion orally throughout the feeding period (100 mg/kg body weight/day, dissolved in groundnut oil). Hepatic choline kinase (EC 2.7.1.32) and cholinephosphate cytidyltransferase (EC 2.7.7.15) activities were inhibited, whereas cholinephosphotransferase (EC 2.7.8.2) activity was not affected by malathion administration. Incorporation of [methyl-14C]L-methionine into hepatic microsomal phosphatidylcholine was significantly reduced by malathion administration.

Full Text

Duke Authors

Cited Authors

  • Singh, Y; Chaudhary, VK; Tyagi, SR; Misra, UK

Published Date

  • February 1, 1984

Published In

Volume / Issue

  • 20 / 2

Start / End Page

  • 219 - 223

PubMed ID

  • 6320501

International Standard Serial Number (ISSN)

  • 0378-4274

Digital Object Identifier (DOI)

  • 10.1016/0378-4274(84)90150-4

Language

  • eng

Conference Location

  • Netherlands