Inhibition of hepatic phosphatidylcholine synthesis by malathion in rats.
Journal Article (Journal Article)
Rats maintained on a 20% casein diet were given malathion orally throughout the feeding period (100 mg/kg body weight/day, dissolved in groundnut oil). Hepatic choline kinase (EC 2.7.1.32) and cholinephosphate cytidyltransferase (EC 2.7.7.15) activities were inhibited, whereas cholinephosphotransferase (EC 2.7.8.2) activity was not affected by malathion administration. Incorporation of [methyl-14C]L-methionine into hepatic microsomal phosphatidylcholine was significantly reduced by malathion administration.
Full Text
Duke Authors
Cited Authors
- Singh, Y; Chaudhary, VK; Tyagi, SR; Misra, UK
Published Date
- February 1, 1984
Published In
Volume / Issue
- 20 / 2
Start / End Page
- 219 - 223
PubMed ID
- 6320501
International Standard Serial Number (ISSN)
- 0378-4274
Digital Object Identifier (DOI)
- 10.1016/0378-4274(84)90150-4
Language
- eng
Conference Location
- Netherlands