Inhibition of hepatic phosphatidylcholine synthesis by malathion in rats.
Rats maintained on a 20% casein diet were given malathion orally throughout the feeding period (100 mg/kg body weight/day, dissolved in groundnut oil). Hepatic choline kinase (EC 188.8.131.52) and cholinephosphate cytidyltransferase (EC 184.108.40.206) activities were inhibited, whereas cholinephosphotransferase (EC 220.127.116.11) activity was not affected by malathion administration. Incorporation of [methyl-14C]L-methionine into hepatic microsomal phosphatidylcholine was significantly reduced by malathion administration.
Singh, Y; Chaudhary, VK; Tyagi, SR; Misra, UK
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