Lung subcellular fractions and surfactant lipid metabolism of rats exposed with DDT or endosulfan intratracheally.


Journal Article

The effect of intratracheally administered DDT (5 mg/100 g body weight) or endosulfan (1 mg/100 g body weight) for three consecutive days has been studied on lipid metabolism of rat lung subcellular fractions. Both the insecticides did not affect the lung weight and the protein contents of microsomes, lamellar bodies and surfactant but significantly increased the phospholipid contents of microsomal and surfactant system. Most of the neutral lipid components of lung subcellular fractions were also increased by DDT or endosulfan treatments, except that of surfactant triglycerides which were decreased by DDT treatment. DDT or endosulfan both increased the incorporation of radioactive [methyl-3H]choline into microsomal phosphatidylcholine (PC) and surfactant dipalmitoylphosphatidylcholine (DPPC) without affecting the incorporation of radioactive [methyl-14C]methionine, showing the increased synthesis of PC via CDPcholine pathway. The results presented in this communication showed that DDT and endosulfan, the two different chloroinsecticides have similar effects on microsomal lipid metabolism but produce different biochemical manifestations on the secretion of surfactant phospholipids.

Full Text

Duke Authors

Cited Authors

  • Narayan, S; Dani, HM; Misra, UK

Published Date

  • April 1990

Published In

Volume / Issue

  • 25 / 2

Start / End Page

  • 259 - 272

PubMed ID

  • 2380488

Pubmed Central ID

  • 2380488

International Standard Serial Number (ISSN)

  • 0360-1234

Digital Object Identifier (DOI)

  • 10.1080/03601239009372688


  • eng

Conference Location

  • England