Effect of vitamin A on hepatic microsomal drug metabolising enzymes activity in rats exposed to acute hypoxia.

Journal Article (Journal Article)

The hepatic drug metabolising enzymes activity has been studied in rats exposed to acute hypoxia alone or along with supplementation of single dose of 10 000 I.U. Vitamin A. Hypoxic stress reduces the activities of cytochrome P-450, cytochrome c-reductase and aniline hydroxylase. Administration of single dose of 10 000 I.U. of Vitamin A to the rats 12 h before hypoxia reverses the effect of hypoxia on these enzymes. Thus Vitamin A seems to play a protective role in rats exposed to hypoxia on the activity of MFO system.

Full Text

Duke Authors

Cited Authors

  • Grover, SK; Srivastava, KK; Singh, VS; Misra, UK

Published Date

  • 1985

Published In

Volume / Issue

  • 55 / 4

Start / End Page

  • 391 - 393

PubMed ID

  • 4086207

International Standard Serial Number (ISSN)

  • 0300-9831


  • eng

Conference Location

  • Switzerland