Impaired Myelination in rats given excess vitamin A postnatally.
The effect of postnatal administration of 1000 I.U. of Vitamin A on 4th, 6th, 8th, and 10th day of age to rat pups has been studied on brain myelin lipid and sulphatide synthesis from Na235SO4. Administration of vitamin A reduced brain weight, free cholesterol, phosphatidal ethanolamine and the synthesis of myelin sulphatides from Na235SO4.
Joshi, HC; Shukla, RR; Srivastava, N; Misra, UK
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