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Phosphatidylcholine metabolism in lung microsomes and lung surfactant of rats exposed intratracheally to coal fly ash.

Publication ,  Journal Article
Srivastava, PK; Misra, UK
Published in: J Toxicol Environ Health
1986

The effect of intratracheal administration of fly ash has been studied on lung microsomal and lung surfactant phosphatidylcholine (PC) metabolism in rats using [methyl-14C]choline and [methyl-14C]methionine. Fly-ash administration significantly increased total phospholipids, PC, phosphatidylethanolamine (PE), and phosphatidylglycerol (PG) of lung surfactant. Fly-ash administration stimulated the formation of lung microsomal PC (as measured by the incorporation of labeled precursors) both by the cytidine 5'-diphosphate (CDP)-choline pathway and by the N-methylation pathway, but this stimulation was fourfold higher in the latter case and only twofold higher in the former as compared to the control. Likewise, the secretion of PC formed by the N-methylation pathway was sixfold higher as compared to the control whereas secretion of PC formed by the CDP-choline pathway was only threefold higher as compared to the control. Fly-ash administration further increased total saturation and decreased unsaturation in PC, PE, and lysophosphatidylcholine (LPC) of lung and in PC, PE, LPC, and PG of lung surfactant as compared to the controls.

Duke Scholars

Published In

J Toxicol Environ Health

DOI

ISSN

0098-4108

Publication Date

1986

Volume

18

Issue

3

Start / End Page

471 / 481

Location

United States

Related Subject Headings

  • Toxicology
  • Rats, Inbred Strains
  • Rats
  • Pulmonary Surfactants
  • Phosphatidylcholines
  • Particulate Matter
  • Microsomes
  • Methylation
  • Male
  • Lung
 

Citation

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Srivastava, P. K., & Misra, U. K. (1986). Phosphatidylcholine metabolism in lung microsomes and lung surfactant of rats exposed intratracheally to coal fly ash. J Toxicol Environ Health, 18(3), 471–481. https://doi.org/10.1080/15287398609530886
Srivastava, P. K., and U. K. Misra. “Phosphatidylcholine metabolism in lung microsomes and lung surfactant of rats exposed intratracheally to coal fly ash.J Toxicol Environ Health 18, no. 3 (1986): 471–81. https://doi.org/10.1080/15287398609530886.
Srivastava, P. K., and U. K. Misra. “Phosphatidylcholine metabolism in lung microsomes and lung surfactant of rats exposed intratracheally to coal fly ash.J Toxicol Environ Health, vol. 18, no. 3, 1986, pp. 471–81. Pubmed, doi:10.1080/15287398609530886.

Published In

J Toxicol Environ Health

DOI

ISSN

0098-4108

Publication Date

1986

Volume

18

Issue

3

Start / End Page

471 / 481

Location

United States

Related Subject Headings

  • Toxicology
  • Rats, Inbred Strains
  • Rats
  • Pulmonary Surfactants
  • Phosphatidylcholines
  • Particulate Matter
  • Microsomes
  • Methylation
  • Male
  • Lung