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Use of biomarkers to establish potential role and function of circulating microRNAs in acute heart failure.

Publication ,  Journal Article
Vegter, EL; Schmitter, D; Hagemeijer, Y; Ovchinnikova, ES; van der Harst, P; Teerlink, JR; O'Connor, CM; Metra, M; Davison, BA; Bloomfield, D ...
Published in: Int J Cardiol
December 1, 2016

BACKGROUND: Circulating microRNAs (miRNAs) emerge as potential heart failure biomarkers. We aimed to identify associations between acute heart failure (AHF)-specific circulating miRNAs and well-known heart failure biomarkers. METHODS: Associations between 16 biomarkers predictive for 180day mortality and the levels of 12 AHF-specific miRNAs were determined in 100 hospitalized AHF patients, at baseline and 48hours. Patients were divided in 4 pre-defined groups, based on clinical parameters during hospitalization. Correlation analyses between miRNAs and biomarkers were performed and complemented by miRNA target prediction and pathway analysis. RESULTS: No significant correlations were found at hospital admission. However, after 48hours, 7 miRNAs were significantly negatively correlated to biomarkers indicative for a worse clinical outcome in the patient group with the most unfavorable in-hospital course (n=21); miR-16-5p was correlated to C-reactive protein (R=-0.66, p-value=0.0027), miR-106a-5p to creatinine (R=-0.68, p-value=0.002), miR-223-3p to growth differentiation factor 15 (R=-0.69, p-value=0.0015), miR-652-3p to soluble ST-2 (R=-0.77, p-value<0.001), miR-199a-3p to procalcitonin (R=-0.72, p-value<0.001) and galectin-3 (R=-0.73, p-value<0.001) and miR-18a-5p to procalcitonin (R=-0.68, p-value=0.002). MiRNA target prediction and pathway analysis identified several pathways related to cardiac diseases, which could be linked to some of the miRNA-biomarker correlations. CONCLUSIONS: The majority of correlations between circulating AHF-specific miRNAs were related to biomarkers predictive for a worse clinical outcome in a subgroup of worsening heart failure patients at 48hours of hospitalization. The selective findings suggest a time-dependent effect of circulating miRNAs and highlight the susceptibility to individual patient characteristics influencing potential relations between miRNAs and biomarkers.

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Published In

Int J Cardiol

DOI

EISSN

1874-1754

Publication Date

December 1, 2016

Volume

224

Start / End Page

231 / 239

Location

Netherlands

Related Subject Headings

  • Xanthines
  • Middle Aged
  • MicroRNAs
  • Male
  • Humans
  • Hospitalization
  • Heart Failure
  • Female
  • Diuretics
  • Databases, Factual
 

Citation

APA
Chicago
ICMJE
MLA
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Vegter, E. L., Schmitter, D., Hagemeijer, Y., Ovchinnikova, E. S., van der Harst, P., Teerlink, J. R., … Khan, M. A. F. (2016). Use of biomarkers to establish potential role and function of circulating microRNAs in acute heart failure. Int J Cardiol, 224, 231–239. https://doi.org/10.1016/j.ijcard.2016.09.010
Vegter, Eline L., Daniela Schmitter, Yanick Hagemeijer, Ekaterina S. Ovchinnikova, Pim van der Harst, John R. Teerlink, Christopher M. O’Connor, et al. “Use of biomarkers to establish potential role and function of circulating microRNAs in acute heart failure.Int J Cardiol 224 (December 1, 2016): 231–39. https://doi.org/10.1016/j.ijcard.2016.09.010.
Vegter EL, Schmitter D, Hagemeijer Y, Ovchinnikova ES, van der Harst P, Teerlink JR, et al. Use of biomarkers to establish potential role and function of circulating microRNAs in acute heart failure. Int J Cardiol. 2016 Dec 1;224:231–9.
Vegter, Eline L., et al. “Use of biomarkers to establish potential role and function of circulating microRNAs in acute heart failure.Int J Cardiol, vol. 224, Dec. 2016, pp. 231–39. Pubmed, doi:10.1016/j.ijcard.2016.09.010.
Vegter EL, Schmitter D, Hagemeijer Y, Ovchinnikova ES, van der Harst P, Teerlink JR, O’Connor CM, Metra M, Davison BA, Bloomfield D, Cotter G, Cleland JG, Givertz MM, Ponikowski P, van Veldhuisen DJ, van der Meer P, Berezikov E, Voors AA, Khan MAF. Use of biomarkers to establish potential role and function of circulating microRNAs in acute heart failure. Int J Cardiol. 2016 Dec 1;224:231–239.
Journal cover image

Published In

Int J Cardiol

DOI

EISSN

1874-1754

Publication Date

December 1, 2016

Volume

224

Start / End Page

231 / 239

Location

Netherlands

Related Subject Headings

  • Xanthines
  • Middle Aged
  • MicroRNAs
  • Male
  • Humans
  • Hospitalization
  • Heart Failure
  • Female
  • Diuretics
  • Databases, Factual