Genetic/Familial High-Risk Assessment: Colorectal Version 1.2016, NCCN Clinical Practice Guidelines in Oncology.


Journal Article

This is a focused update highlighting the most current NCCN Guidelines for diagnosis and management of Lynch syndrome. Lynch syndrome is the most common cause of hereditary colorectal cancer, usually resulting from a germline mutation in 1 of 4 DNA mismatch repair genes (MLH1, MSH2, MSH6, or PMS2), or deletions in the EPCAM promoter. Patients with Lynch syndrome are at an increased lifetime risk, compared with the general population, for colorectal cancer, endometrial cancer, and other cancers, including of the stomach and ovary. As of 2016, the panel recommends screening all patients with colorectal cancer for Lynch syndrome and provides recommendations for surveillance for early detection and prevention of Lynch syndrome-associated cancers.

Full Text

Duke Authors

Cited Authors

  • Provenzale, D; Gupta, S; Ahnen, DJ; Bray, T; Cannon, JA; Cooper, G; David, DS; Early, DS; Erwin, D; Ford, JM; Giardiello, FM; Grady, W; Halverson, AL; Hamilton, SR; Hampel, H; Ismail, MK; Klapman, JB; Larson, DW; Lazenby, AJ; Lynch, PM; Mayer, RJ; Ness, RM; Regenbogen, SE; Samadder, NJ; Shike, M; Steinbach, G; Weinberg, D; Dwyer, M; Darlow, S

Published Date

  • August 2016

Published In

Volume / Issue

  • 14 / 8

Start / End Page

  • 1010 - 1030

PubMed ID

  • 27496117

Pubmed Central ID

  • 27496117

Electronic International Standard Serial Number (EISSN)

  • 1540-1413

Digital Object Identifier (DOI)

  • 10.6004/jnccn.2016.0108


  • eng

Conference Location

  • United States