A guide to immunometabolism for immunologists.

Journal Article (Journal Article;Review)

In recent years a substantial number of findings have been made in the area of immunometabolism, by which we mean the changes in intracellular metabolic pathways in immune cells that alter their function. Here, we provide a brief refresher course on six of the major metabolic pathways involved (specifically, glycolysis, the tricarboxylic acid (TCA) cycle, the pentose phosphate pathway, fatty acid oxidation, fatty acid synthesis and amino acid metabolism), giving specific examples of how precise changes in the metabolites of these pathways shape the immune cell response. What is emerging is a complex interplay between metabolic reprogramming and immunity, which is providing an extra dimension to our understanding of the immune system in health and disease.

Full Text

Duke Authors

Cited Authors

  • O'Neill, LAJ; Kishton, RJ; Rathmell, J

Published Date

  • September 2016

Published In

Volume / Issue

  • 16 / 9

Start / End Page

  • 553 - 565

PubMed ID

  • 27396447

Pubmed Central ID

  • PMC5001910

Electronic International Standard Serial Number (EISSN)

  • 1474-1741

Digital Object Identifier (DOI)

  • 10.1038/nri.2016.70


  • eng

Conference Location

  • England