L-Asparaginase-induced coagulopathy during therapy of acute lymphocytic leukemia.
L-Asparaginase-induced coagulation abnormalities were observed in all patients receivng this drug. All patients studied demonstrated low factor IX and fibrinogen levels and most (75%) had low levels of factor XI. Disturbances in other factors were much less frequent. Despite the presence of markedly abnormal coagulation studies, clinical bleeding was not observed.
Sills, RH; Nelson, DA; Stockman, JA
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