L-Asparaginase-induced coagulopathy during therapy of acute lymphocytic leukemia.

Journal Article (Journal Article)

L-Asparaginase-induced coagulation abnormalities were observed in all patients receivng this drug. All patients studied demonstrated low factor IX and fibrinogen levels and most (75%) had low levels of factor XI. Disturbances in other factors were much less frequent. Despite the presence of markedly abnormal coagulation studies, clinical bleeding was not observed.

Full Text

Duke Authors

Cited Authors

  • Sills, RH; Nelson, DA; Stockman, JA

Published Date

  • 1978

Published In

Volume / Issue

  • 4 / 4

Start / End Page

  • 311 - 313

PubMed ID

  • 281595

International Standard Serial Number (ISSN)

  • 0098-1532

Digital Object Identifier (DOI)

  • 10.1002/mpo.2950040406


  • eng

Conference Location

  • United States