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Coccidioidomycosis Transmission Through Organ Transplantation: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee.

Publication ,  Journal Article
Kusne, S; Taranto, S; Covington, S; Kaul, DR; Blumberg, EA; Wolfe, C; Green, M
Published in: Am J Transplant
December 2016

Donor-derived coccidioidomycosis has caused unexpected morbidity and mortality in transplant recipients. All proven or probable reports of donor-derived coccidioidomycosis to the Disease Transmission Advisory Committee between 2005 and August 2012 were reviewed. Six reports of proven or probable coccidioidomycosis were discovered. In four of six, the infection was first detected at autopsy in the recipient. In two cases it was first identified in the donor. Twenty-one recipients received organs from these six donors. Transmission occurred in 43% at a median of 30 days posttransplant with a mortality rate of 28.5%. Eleven recipients received preemptive antifungals, seven did not receive treatment, and treatment information was not reported for three recipients. Five of seven who did not receive prophylaxis/treatment died and all 11 who received early therapy survived. Six deaths occurred 14 to 55 days after transplant, with a median of 21 days. For exposed recipients, donor-derived coccidioidomycosis is a significant cause of morbidity and mortality. Evidence of infection in one recipient should prompt immediate evaluation for treatment of all other recipients from the same donor as preemptive treatment was effective. Further studies are needed to decide whether all donors from endemic areas should have routine serologic screening.

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Published In

Am J Transplant

DOI

EISSN

1600-6143

Publication Date

December 2016

Volume

16

Issue

12

Start / End Page

3562 / 3567

Location

United States

Related Subject Headings

  • United States
  • Transplant Recipients
  • Tissue and Organ Procurement
  • Tissue Donors
  • Surgery
  • Risk Assessment
  • Prognosis
  • Patient Safety
  • Organ Transplantation
  • Humans
 

Citation

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Chicago
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Kusne, S., Taranto, S., Covington, S., Kaul, D. R., Blumberg, E. A., Wolfe, C., & Green, M. (2016). Coccidioidomycosis Transmission Through Organ Transplantation: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee. Am J Transplant, 16(12), 3562–3567. https://doi.org/10.1111/ajt.13950
Kusne, S., S. Taranto, S. Covington, D. R. Kaul, E. A. Blumberg, C. Wolfe, and M. Green. “Coccidioidomycosis Transmission Through Organ Transplantation: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee.Am J Transplant 16, no. 12 (December 2016): 3562–67. https://doi.org/10.1111/ajt.13950.
Kusne S, Taranto S, Covington S, Kaul DR, Blumberg EA, Wolfe C, et al. Coccidioidomycosis Transmission Through Organ Transplantation: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee. Am J Transplant. 2016 Dec;16(12):3562–7.
Kusne, S., et al. “Coccidioidomycosis Transmission Through Organ Transplantation: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee.Am J Transplant, vol. 16, no. 12, Dec. 2016, pp. 3562–67. Pubmed, doi:10.1111/ajt.13950.
Kusne S, Taranto S, Covington S, Kaul DR, Blumberg EA, Wolfe C, Green M. Coccidioidomycosis Transmission Through Organ Transplantation: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee. Am J Transplant. 2016 Dec;16(12):3562–3567.
Journal cover image

Published In

Am J Transplant

DOI

EISSN

1600-6143

Publication Date

December 2016

Volume

16

Issue

12

Start / End Page

3562 / 3567

Location

United States

Related Subject Headings

  • United States
  • Transplant Recipients
  • Tissue and Organ Procurement
  • Tissue Donors
  • Surgery
  • Risk Assessment
  • Prognosis
  • Patient Safety
  • Organ Transplantation
  • Humans