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Assessment of cardiac allograft systolic function by global longitudinal strain: From donor to recipient.

Publication ,  Conference
DeVore, AD; Alenezi, F; Krishnamoorthy, A; Ersboll, M; Samsky, MD; Schulte, PJ; Patel, CB; Rogers, JG; Milano, CA; Velazquez, EJ; Khouri, MG
Published in: Clin Transplant
May 2017

BACKGROUND: Cardiac allografts are routinely evaluated by left ventricular ejection fraction (LVEF) before and after transplantation. However, myocardial deformation analyses with LV global longitudinal strain (GLS) are more sensitive for detecting impaired LV myocardial systolic performance compared with LVEF. METHODS: We analyzed echocardiograms in 34 heart donor-recipient pairs transplanted at Duke University from 2000 to 2013. Assessments of allograft LV systolic function by LVEF and/or LV GLS were performed on echocardiograms obtained pre-explanation in donors and serially in corresponding recipients. RESULTS: Donors had a median LVEF of 55% (25th, 75th percentile, 54% to 60%). Median donor LV GLS was -14.6% (-13.7 to -17.3%); LV GLS was abnormal (ie, >-16%) in 68% of donors. Post-transplantation, LV GLS was further impaired at 6 weeks (median -11.8%; -11.0 to -13.4%) and 3 months (median -11.4%; -10.3 to -13.9%) before recovering to pretransplant levels in follow-up. Median LVEF remained ≥50% throughout follow-up. We found no association between donor LV GLS and post-transplant outcomes, including all-cause hospitalization and mortality. CONCLUSIONS: GLS demonstrates allograft LV systolic dysfunction in donors and recipients not detected by LVEF. The clinical implications of subclinical allograft dysfunction detected by LV GLS require further study.

Duke Scholars

Published In

Clin Transplant

DOI

EISSN

1399-0012

Publication Date

May 2017

Volume

31

Issue

5

Location

Denmark

Related Subject Headings

  • Young Adult
  • Ventricular Dysfunction, Left
  • Transplant Recipients
  • Tissue Donors
  • Surgery
  • Stroke Volume
  • Retrospective Studies
  • Prospective Studies
  • Prognosis
  • Middle Aged
 

Citation

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DeVore, A. D., Alenezi, F., Krishnamoorthy, A., Ersboll, M., Samsky, M. D., Schulte, P. J., … Khouri, M. G. (2017). Assessment of cardiac allograft systolic function by global longitudinal strain: From donor to recipient. In Clin Transplant (Vol. 31). Denmark. https://doi.org/10.1111/ctr.12961
DeVore, Adam D., Fawaz Alenezi, Arun Krishnamoorthy, Mads Ersboll, Marc D. Samsky, Phillip J. Schulte, Chetan B. Patel, et al. “Assessment of cardiac allograft systolic function by global longitudinal strain: From donor to recipient.” In Clin Transplant, Vol. 31, 2017. https://doi.org/10.1111/ctr.12961.
DeVore AD, Alenezi F, Krishnamoorthy A, Ersboll M, Samsky MD, Schulte PJ, et al. Assessment of cardiac allograft systolic function by global longitudinal strain: From donor to recipient. In: Clin Transplant. 2017.
DeVore, Adam D., et al. “Assessment of cardiac allograft systolic function by global longitudinal strain: From donor to recipient.Clin Transplant, vol. 31, no. 5, 2017. Pubmed, doi:10.1111/ctr.12961.
DeVore AD, Alenezi F, Krishnamoorthy A, Ersboll M, Samsky MD, Schulte PJ, Patel CB, Rogers JG, Milano CA, Velazquez EJ, Khouri MG. Assessment of cardiac allograft systolic function by global longitudinal strain: From donor to recipient. Clin Transplant. 2017.
Journal cover image

Published In

Clin Transplant

DOI

EISSN

1399-0012

Publication Date

May 2017

Volume

31

Issue

5

Location

Denmark

Related Subject Headings

  • Young Adult
  • Ventricular Dysfunction, Left
  • Transplant Recipients
  • Tissue Donors
  • Surgery
  • Stroke Volume
  • Retrospective Studies
  • Prospective Studies
  • Prognosis
  • Middle Aged