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Nucleic acid scavenging microfiber mesh inhibits trauma-induced inflammation and thrombosis.

Publication ,  Journal Article
Lee, J; Jackman, JG; Kwun, J; Manook, M; Moreno, A; Elster, EA; Kirk, AD; Leong, KW; Sullenger, BA
Published in: Biomaterials
March 2017

Trauma patients produce a host of danger signals and high levels of damage-associated molecular patterns (DAMPs) after cellular injury and tissue damage. These DAMPs are directly and indirectly involved in the pathogenesis of various inflammatory and thrombotic complications in patients with severe injuries. No effective therapeutic agents for the removal of DAMPs from blood or tissue fluid have been developed. Herein, we demonstrated that nucleic acid binding polymers, e.g., polyethylenimine (PEI) and polyamidoamine dendrimers, immobilized onto electrospun microfiber mesh can effectively capture various DAMPs, such as extracellular DNAs and high mobility group box 1 (HMGB1). Furthermore, treatment with PEI-immobilized microfiber mesh abrogated the ability of DAMPs, released from dead and dying cells in culture or found in patients following traumatic injury, to activate innate immune responses and coagulation in vitro and in vivo. Nucleic acid scavenging microfiber meshes represent an effective strategy to combat inflammation and thrombosis in trauma.

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Published In

Biomaterials

DOI

EISSN

1878-5905

Publication Date

March 2017

Volume

120

Start / End Page

94 / 102

Location

Netherlands

Related Subject Headings

  • Ultrafiltration
  • Treatment Outcome
  • Thrombosis
  • Nucleic Acids
  • Nanofibers
  • Mice
  • Materials Testing
  • Inflammation
  • Humans
  • Dendrimers
 

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Lee, J., Jackman, J. G., Kwun, J., Manook, M., Moreno, A., Elster, E. A., … Sullenger, B. A. (2017). Nucleic acid scavenging microfiber mesh inhibits trauma-induced inflammation and thrombosis. Biomaterials, 120, 94–102. https://doi.org/10.1016/j.biomaterials.2016.12.024
Lee, Jaewoo, Jennifer G. Jackman, Jean Kwun, Miriam Manook, Angelo Moreno, Eric A. Elster, Allan D. Kirk, Kam W. Leong, and Bruce A. Sullenger. “Nucleic acid scavenging microfiber mesh inhibits trauma-induced inflammation and thrombosis.Biomaterials 120 (March 2017): 94–102. https://doi.org/10.1016/j.biomaterials.2016.12.024.
Lee J, Jackman JG, Kwun J, Manook M, Moreno A, Elster EA, et al. Nucleic acid scavenging microfiber mesh inhibits trauma-induced inflammation and thrombosis. Biomaterials. 2017 Mar;120:94–102.
Lee, Jaewoo, et al. “Nucleic acid scavenging microfiber mesh inhibits trauma-induced inflammation and thrombosis.Biomaterials, vol. 120, Mar. 2017, pp. 94–102. Pubmed, doi:10.1016/j.biomaterials.2016.12.024.
Lee J, Jackman JG, Kwun J, Manook M, Moreno A, Elster EA, Kirk AD, Leong KW, Sullenger BA. Nucleic acid scavenging microfiber mesh inhibits trauma-induced inflammation and thrombosis. Biomaterials. 2017 Mar;120:94–102.
Journal cover image

Published In

Biomaterials

DOI

EISSN

1878-5905

Publication Date

March 2017

Volume

120

Start / End Page

94 / 102

Location

Netherlands

Related Subject Headings

  • Ultrafiltration
  • Treatment Outcome
  • Thrombosis
  • Nucleic Acids
  • Nanofibers
  • Mice
  • Materials Testing
  • Inflammation
  • Humans
  • Dendrimers