Enhanced visualization of peripheral retinal vasculature with wavefront sensorless adaptive optics optical coherence tomography angiography in diabetic patients.
Published
Journal Article
Optical coherence tomography angiography (OCTA) is a promising technique for non-invasive visualization of vessel networks in the human eye. We debut a system capable of acquiring wide field-of-view (>70°) OCT angiograms without mosaicking. Additionally, we report on enhancing the visualization of peripheral microvasculature using wavefront sensorless adaptive optics (WSAO). We employed a fast WSAO algorithm that enabled wavefront correction in <2 s by iterating the mirror shape at the speed of OCT B-scans rather than volumes. Also, we contrasted ∼7° field-of-view OCTA angiograms acquired in the periphery with and without WSAO correction. On average, WSAO improved the sharpness of microvasculature by 65% in healthy eyes and 38% in diseased eyes. Preliminary observations demonstrated that the location of 7° images could be identified directly from the wide field-of-view angiogram. A pilot study on a normal subject and patients with diabetic retinopathy showed the impact of utilizing WSAO for OCTA when visualizing peripheral vasculature pathologies.
Full Text
Duke Authors
- Allingham, Michael John
- Cousins, Scott William
- Farsiu, Sina
- Izatt, Joseph A.
- Keller, Brenton
- Mettu, Priyatham S
Cited Authors
- Polans, J; Cunefare, D; Cole, E; Keller, B; Mettu, PS; Cousins, SW; Allingham, MJ; Izatt, JA; Farsiu, S
Published Date
- January 1, 2017
Published In
Volume / Issue
- 42 / 1
Start / End Page
- 17 - 20
PubMed ID
- 28059209
Pubmed Central ID
- 28059209
Electronic International Standard Serial Number (EISSN)
- 1539-4794
Digital Object Identifier (DOI)
- 10.1364/OL.42.000017
Language
- eng
Conference Location
- United States