Enhanced visualization of peripheral retinal vasculature with wavefront sensorless adaptive optics optical coherence tomography angiography in diabetic patients.

Journal Article (Journal Article)

Optical coherence tomography angiography (OCTA) is a promising technique for non-invasive visualization of vessel networks in the human eye. We debut a system capable of acquiring wide field-of-view (>70°) OCT angiograms without mosaicking. Additionally, we report on enhancing the visualization of peripheral microvasculature using wavefront sensorless adaptive optics (WSAO). We employed a fast WSAO algorithm that enabled wavefront correction in <2  s by iterating the mirror shape at the speed of OCT B-scans rather than volumes. Also, we contrasted ∼7° field-of-view OCTA angiograms acquired in the periphery with and without WSAO correction. On average, WSAO improved the sharpness of microvasculature by 65% in healthy eyes and 38% in diseased eyes. Preliminary observations demonstrated that the location of 7° images could be identified directly from the wide field-of-view angiogram. A pilot study on a normal subject and patients with diabetic retinopathy showed the impact of utilizing WSAO for OCTA when visualizing peripheral vasculature pathologies.

Full Text

Duke Authors

Cited Authors

  • Polans, J; Cunefare, D; Cole, E; Keller, B; Mettu, PS; Cousins, SW; Allingham, MJ; Izatt, JA; Farsiu, S

Published Date

  • January 1, 2017

Published In

Volume / Issue

  • 42 / 1

Start / End Page

  • 17 - 20

PubMed ID

  • 28059209

Pubmed Central ID

  • PMC5510471

Electronic International Standard Serial Number (EISSN)

  • 1539-4794

Digital Object Identifier (DOI)

  • 10.1364/OL.42.000017


  • eng

Conference Location

  • United States