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SU-C-204-06: Monte Carlo Dose Calculation for Kilovoltage X-Ray-Psoralen Activated Cancer Therapy (X-PACT): Preliminary Results.

Publication ,  Journal Article
Mein, S; Gunasingha, R; Nolan, M; Oldham, M; Adamson, J
Published in: Med Phys
June 2016

PURPOSE: X-PACT is an experimental cancer therapy where kV x-rays are used to photo-activate anti-cancer therapeutics through phosphor intermediaries (phosphors that absorb x-rays and re-radiate as UV light). Clinical trials in pet dogs are currently underway (NC State College of Veterinary Medicine) and an essential component is the ability to model the kV dose in these dogs. Here we report the commissioning and characterization of a Monte Carlo (MC) treatment planning simulation tool to calculate X-PACT radiation doses in canine trials. METHODS: FLUKA multi-particle MC simulation package was used to simulate a standard X-PACT radiation treatment beam of 80kVp with the Varian OBI x-ray source geometry. The beam quality was verified by comparing measured and simulated attenuation of the beam by various thicknesses of aluminum (2-4.6 mm) under narrow beam conditions (HVL). The beam parameters at commissioning were then corroborated using MC, characterized and verified with empirically collected commissioning data, including: percent depth dose curves (PDD), back-scatter factors (BSF), collimator scatter factor(s), and heel effect, etc. All simulations were conducted for N=30M histories at M=100 iterations. RESULTS: HVL and PDD simulation data agreed with an average percent error of 2.42%±0.33 and 6.03%±1.58, respectively. The mean square error (MSE) values for HVL and PDD (0.07% and 0.50%) were low, as expected; however, longer simulations are required to validate convergence to the expected values. Qualitatively, pre- and post-filtration source spectra matched well with 80kVp references generated via SPEKTR software. Further validation of commissioning data simulation is underway in preparation for first-time 3D dose calculations with canine CBCT data. CONCLUSION: We have prepared a Monte Carlo simulation capable of accurate dose calculation for use with ongoing X-PACT canine clinical trials. Preliminary results show good agreement with measured data and hold promise for accurate quantification of dose for this novel psoralen X-ray therapy. Funding Support, Disclosures, & Conflict of Interest: The Monte Carlo simulation work was not funded; Drs. Adamson & Oldham have received funding from Immunolight LLC for X-PACT research.

Duke Scholars

Published In

Med Phys

DOI

EISSN

2473-4209

Publication Date

June 2016

Volume

43

Issue

6

Start / End Page

3314 / 3315

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mein, S., Gunasingha, R., Nolan, M., Oldham, M., & Adamson, J. (2016). SU-C-204-06: Monte Carlo Dose Calculation for Kilovoltage X-Ray-Psoralen Activated Cancer Therapy (X-PACT): Preliminary Results. Med Phys, 43(6), 3314–3315. https://doi.org/10.1118/1.4955539
Mein, S., R. Gunasingha, M. Nolan, M. Oldham, and J. Adamson. “SU-C-204-06: Monte Carlo Dose Calculation for Kilovoltage X-Ray-Psoralen Activated Cancer Therapy (X-PACT): Preliminary Results.Med Phys 43, no. 6 (June 2016): 3314–15. https://doi.org/10.1118/1.4955539.
Mein S, Gunasingha R, Nolan M, Oldham M, Adamson J. SU-C-204-06: Monte Carlo Dose Calculation for Kilovoltage X-Ray-Psoralen Activated Cancer Therapy (X-PACT): Preliminary Results. Med Phys. 2016 Jun;43(6):3314–5.
Mein, S., et al. “SU-C-204-06: Monte Carlo Dose Calculation for Kilovoltage X-Ray-Psoralen Activated Cancer Therapy (X-PACT): Preliminary Results.Med Phys, vol. 43, no. 6, June 2016, pp. 3314–15. Pubmed, doi:10.1118/1.4955539.
Mein S, Gunasingha R, Nolan M, Oldham M, Adamson J. SU-C-204-06: Monte Carlo Dose Calculation for Kilovoltage X-Ray-Psoralen Activated Cancer Therapy (X-PACT): Preliminary Results. Med Phys. 2016 Jun;43(6):3314–3315.

Published In

Med Phys

DOI

EISSN

2473-4209

Publication Date

June 2016

Volume

43

Issue

6

Start / End Page

3314 / 3315

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences