Knotty Zika Virus Blocks Exonuclease to Produce Subgenomic Flaviviral RNAs.

Journal Article (Journal Article)

In a recent issue of Science, Akiyama et al. (2016) prove the existence of a pseudoknot that stabilizes a nuclease-resistant RNA structure in the 3' untranslated region of Zika virus. This reinforced structure blocks the 5'→3' exonuclease Xrn1 for the production of pathogenic subgenomic flaviviral RNAs.

Full Text

Duke Authors

Cited Authors

  • Gokhale, NS; Horner, SM

Published Date

  • January 11, 2017

Published In

Volume / Issue

  • 21 / 1

Start / End Page

  • 1 - 2

PubMed ID

  • 28081439

Pubmed Central ID

  • PMC6123830

Electronic International Standard Serial Number (EISSN)

  • 1934-6069

Digital Object Identifier (DOI)

  • 10.1016/j.chom.2016.12.013


  • eng

Conference Location

  • United States