Knotty Zika Virus Blocks Exonuclease to Produce Subgenomic Flaviviral RNAs.
Published
Journal Article
In a recent issue of Science, Akiyama et al. (2016) prove the existence of a pseudoknot that stabilizes a nuclease-resistant RNA structure in the 3' untranslated region of Zika virus. This reinforced structure blocks the 5'→3' exonuclease Xrn1 for the production of pathogenic subgenomic flaviviral RNAs.
Full Text
Duke Authors
Cited Authors
- Gokhale, NS; Horner, SM
Published Date
- January 11, 2017
Published In
Volume / Issue
- 21 / 1
Start / End Page
- 1 - 2
PubMed ID
- 28081439
Pubmed Central ID
- 28081439
Electronic International Standard Serial Number (EISSN)
- 1934-6069
Digital Object Identifier (DOI)
- 10.1016/j.chom.2016.12.013
Language
- eng
Conference Location
- United States