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Modifying effect of mouse double minute-2 promoter variants on risk of recurrence for patients with squamous cell carcinoma of oropharynx.

Publication ,  Journal Article
Zhang, Y; Sturgis, EM; Li, Y; Wei, Q; Huang, Z; Li, G
Published in: Sci Rep
January 3, 2017

Functional mouse double minute-2 (MDM2) promoter variants may alter MDM2 expression and thus affect radiotherapy response and prognosis of squamous cell carcinoma of oropharynx (SCCOP). Thus we assessed association of 2 functional MDM2 promoter variants with recurrence risk of SCCOP. The disease-free survival (DFS) of patients with MDM2rs2279744 TT or MDM2rs937283 AA genotypes was significantly reduced compared with that of patients with corresponding GT/GG or AG/GG genotypes. Multivariable analysis showed patients with TT or AA genotypes had a significantly higher risk of SCCOP recurrence than those with corresponding GT/GG or AG/GG genotypes did. Furthermore, patients with combined risk genotypes of the 2 polymorphisms had significantly worse DFS and a higher recurrence risk than patients with fewer combined risk genotypes did (Ptrend < 0.001). Compared with patients with 0 risk genotypes, patients with 1 or 2 risk genotypes had an approximately 3- or 11-fold increased risk of SCCOP recurrence, respectively. Notably, for both individual and combined polymorphisms, the above similar recurrence risks were particularly higher among patients with human papilloma virus (HPV)-positive tumors. Taken together, our findings suggest that MDM2 promoter variants individually, or more likely jointly, play a role in determining the risk of recurrence of SCCOP, particularly HPV-positive SCCOP.

Duke Scholars

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Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

January 3, 2017

Volume

7

Start / End Page

39765

Location

England

Related Subject Headings

  • Survival Analysis
  • Squamous Cell Carcinoma of Head and Neck
  • Risk
  • Proto-Oncogene Proteins c-mdm2
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Papillomavirus Infections
  • Oropharyngeal Neoplasms
  • Neoplasm Recurrence, Local
  • Middle Aged
 

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Zhang, Y., Sturgis, E. M., Li, Y., Wei, Q., Huang, Z., & Li, G. (2017). Modifying effect of mouse double minute-2 promoter variants on risk of recurrence for patients with squamous cell carcinoma of oropharynx. Sci Rep, 7, 39765. https://doi.org/10.1038/srep39765
Zhang, Yang, Erich M. Sturgis, Yuncheng Li, Qingyi Wei, Zhigang Huang, and Guojun Li. “Modifying effect of mouse double minute-2 promoter variants on risk of recurrence for patients with squamous cell carcinoma of oropharynx.Sci Rep 7 (January 3, 2017): 39765. https://doi.org/10.1038/srep39765.
Zhang, Yang, et al. “Modifying effect of mouse double minute-2 promoter variants on risk of recurrence for patients with squamous cell carcinoma of oropharynx.Sci Rep, vol. 7, Jan. 2017, p. 39765. Pubmed, doi:10.1038/srep39765.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

January 3, 2017

Volume

7

Start / End Page

39765

Location

England

Related Subject Headings

  • Survival Analysis
  • Squamous Cell Carcinoma of Head and Neck
  • Risk
  • Proto-Oncogene Proteins c-mdm2
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Papillomavirus Infections
  • Oropharyngeal Neoplasms
  • Neoplasm Recurrence, Local
  • Middle Aged