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Wide-field retinal optical coherence tomography with wavefront sensorless adaptive optics for enhanced imaging of targeted regions.

Publication ,  Journal Article
Polans, J; Keller, B; Carrasco-Zevallos, OM; LaRocca, F; Cole, E; Whitson, HE; Lad, EM; Farsiu, S; Izatt, JA
Published in: Biomed Opt Express
January 1, 2017

The peripheral retina of the human eye offers a unique opportunity for assessment and monitoring of ocular diseases. We have developed a novel wide-field (>70°) optical coherence tomography system (WF-OCT) equipped with wavefront sensorless adaptive optics (WSAO) for enhancing the visualization of smaller (<25°) targeted regions in the peripheral retina. We iterated the WSAO algorithm at the speed of individual OCT B-scans (~20 ms) by using raw spectral interferograms to calculate the optimization metric. Our WSAO approach with a 3 mm beam diameter permitted primarily low- but also high- order peripheral wavefront correction in less than 10 seconds. In preliminary imaging studies in five normal human subjects, we quantified statistically significant changes with WSAO correction, corresponding to a 10.4% improvement in average pixel brightness (signal) and 7.0% improvement in high frequency content (resolution) when visualizing 1 mm (~3.5°) B-scans of the peripheral (>23°) retina. We demonstrated the ability of our WF-OCT system to acquire non wavefront-corrected wide-field images rapidly, which could then be used to locate regions of interest, zoom into targeted features, and visualize the same region at different time points. A pilot clinical study was conducted on seven healthy volunteers and two subjects with prodromal Alzheimer's disease which illustrated the capability to image Drusen-like pathologies as far as 32.5° from the fovea in un-averaged volume scans. This work suggests that the proposed combination of WF-OCT and WSAO may find applications in the diagnosis and treatment of ocular, and potentially neurodegenerative, diseases of the peripheral retina, including diabetes and Alzheimer's disease.

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Published In

Biomed Opt Express

DOI

ISSN

2156-7085

Publication Date

January 1, 2017

Volume

8

Issue

1

Start / End Page

16 / 37

Location

United States

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4003 Biomedical engineering
  • 3212 Ophthalmology and optometry
  • 0912 Materials Engineering
  • 0205 Optical Physics
 

Citation

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Polans, J., Keller, B., Carrasco-Zevallos, O. M., LaRocca, F., Cole, E., Whitson, H. E., … Izatt, J. A. (2017). Wide-field retinal optical coherence tomography with wavefront sensorless adaptive optics for enhanced imaging of targeted regions. Biomed Opt Express, 8(1), 16–37. https://doi.org/10.1364/BOE.8.000016
Polans, James, Brenton Keller, Oscar M. Carrasco-Zevallos, Francesco LaRocca, Elijah Cole, Heather E. Whitson, Eleonora M. Lad, Sina Farsiu, and Joseph A. Izatt. “Wide-field retinal optical coherence tomography with wavefront sensorless adaptive optics for enhanced imaging of targeted regions.Biomed Opt Express 8, no. 1 (January 1, 2017): 16–37. https://doi.org/10.1364/BOE.8.000016.
Polans J, Keller B, Carrasco-Zevallos OM, LaRocca F, Cole E, Whitson HE, et al. Wide-field retinal optical coherence tomography with wavefront sensorless adaptive optics for enhanced imaging of targeted regions. Biomed Opt Express. 2017 Jan 1;8(1):16–37.
Polans, James, et al. “Wide-field retinal optical coherence tomography with wavefront sensorless adaptive optics for enhanced imaging of targeted regions.Biomed Opt Express, vol. 8, no. 1, Jan. 2017, pp. 16–37. Pubmed, doi:10.1364/BOE.8.000016.
Polans J, Keller B, Carrasco-Zevallos OM, LaRocca F, Cole E, Whitson HE, Lad EM, Farsiu S, Izatt JA. Wide-field retinal optical coherence tomography with wavefront sensorless adaptive optics for enhanced imaging of targeted regions. Biomed Opt Express. 2017 Jan 1;8(1):16–37.
Journal cover image

Published In

Biomed Opt Express

DOI

ISSN

2156-7085

Publication Date

January 1, 2017

Volume

8

Issue

1

Start / End Page

16 / 37

Location

United States

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4003 Biomedical engineering
  • 3212 Ophthalmology and optometry
  • 0912 Materials Engineering
  • 0205 Optical Physics