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Enhancing Nervous System Recovery through Neurobiologics, Neural Interface Training, and Neurorehabilitation.

Publication ,  Journal Article
Krucoff, MO; Rahimpour, S; Slutzky, MW; Edgerton, VR; Turner, DA
Published in: Front Neurosci
2016

After an initial period of recovery, human neurological injury has long been thought to be static. In order to improve quality of life for those suffering from stroke, spinal cord injury, or traumatic brain injury, researchers have been working to restore the nervous system and reduce neurological deficits through a number of mechanisms. For example, neurobiologists have been identifying and manipulating components of the intra- and extracellular milieu to alter the regenerative potential of neurons, neuro-engineers have been producing brain-machine and neural interfaces that circumvent lesions to restore functionality, and neurorehabilitation experts have been developing new ways to revitalize the nervous system even in chronic disease. While each of these areas holds promise, their individual paths to clinical relevance remain difficult. Nonetheless, these methods are now able to synergistically enhance recovery of native motor function to levels which were previously believed to be impossible. Furthermore, such recovery can even persist after training, and for the first time there is evidence of functional axonal regrowth and rewiring in the central nervous system of animal models. To attain this type of regeneration, rehabilitation paradigms that pair cortically-based intent with activation of affected circuits and positive neurofeedback appear to be required-a phenomenon which raises new and far reaching questions about the underlying relationship between conscious action and neural repair. For this reason, we argue that multi-modal therapy will be necessary to facilitate a truly robust recovery, and that the success of investigational microscopic techniques may depend on their integration into macroscopic frameworks that include task-based neurorehabilitation. We further identify critical components of future neural repair strategies and explore the most updated knowledge, progress, and challenges in the fields of cellular neuronal repair, neural interfacing, and neurorehabilitation, all with the goal of better understanding neurological injury and how to improve recovery.

Duke Scholars

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Published In

Front Neurosci

DOI

ISSN

1662-4548

Publication Date

2016

Volume

10

Start / End Page

584

Location

Switzerland

Related Subject Headings

  • 5202 Biological psychology
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1701 Psychology
  • 1109 Neurosciences
 

Citation

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Chicago
ICMJE
MLA
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Krucoff, M. O., Rahimpour, S., Slutzky, M. W., Edgerton, V. R., & Turner, D. A. (2016). Enhancing Nervous System Recovery through Neurobiologics, Neural Interface Training, and Neurorehabilitation. Front Neurosci, 10, 584. https://doi.org/10.3389/fnins.2016.00584
Krucoff, Max O., Shervin Rahimpour, Marc W. Slutzky, V Reggie Edgerton, and Dennis A. Turner. “Enhancing Nervous System Recovery through Neurobiologics, Neural Interface Training, and Neurorehabilitation.Front Neurosci 10 (2016): 584. https://doi.org/10.3389/fnins.2016.00584.
Krucoff MO, Rahimpour S, Slutzky MW, Edgerton VR, Turner DA. Enhancing Nervous System Recovery through Neurobiologics, Neural Interface Training, and Neurorehabilitation. Front Neurosci. 2016;10:584.
Krucoff, Max O., et al. “Enhancing Nervous System Recovery through Neurobiologics, Neural Interface Training, and Neurorehabilitation.Front Neurosci, vol. 10, 2016, p. 584. Pubmed, doi:10.3389/fnins.2016.00584.
Krucoff MO, Rahimpour S, Slutzky MW, Edgerton VR, Turner DA. Enhancing Nervous System Recovery through Neurobiologics, Neural Interface Training, and Neurorehabilitation. Front Neurosci. 2016;10:584.

Published In

Front Neurosci

DOI

ISSN

1662-4548

Publication Date

2016

Volume

10

Start / End Page

584

Location

Switzerland

Related Subject Headings

  • 5202 Biological psychology
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1701 Psychology
  • 1109 Neurosciences