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Factors associated with non-completion of follow-up: 33-month latent tuberculous infection treatment trial.

Publication ,  Journal Article
Moro, RN; Sterling, TR; Saukkonen, J; Vernon, A; Horsburgh, CR; Chaisson, RE; Hamilton, CD; Villarino, ME; Goldberg, S
Published in: Int J Tuberc Lung Dis
March 1, 2017

SETTING: A post-hoc exploratory analysis of a randomized, open-label clinical trial that enrolled 8053 participants from the United States, Canada, Brazil, and Spain. OBJECTIVE: To assess factors associated with non-completion of study follow-up (NCF) in a 33-month latent tuberculous infection treatment trial, PREVENT TB. DESIGN: Participants were randomized to receive 3 months of weekly directly observed therapy vs. 9 months of daily self-administered therapy. NCF was defined as failing to be followed for at least 993 days (33 months) from enrollment. Possible factors associated with NCF were analyzed using univariate and multivariate regression via Cox proportional hazard model. RESULTS: Of 7061 adults selected for analysis, 841 (11.9%) did not complete study follow-up. Homelessness, young age, low education, history of incarceration, smoking, missing an early clinic visit, receiving isoniazid only, and male sex were significantly associated with NCF. Similar results were found in the North American region (United States and Canada) only. In Brazil and Spain, the only significant factor was missing an early clinic visit. CONCLUSIONS: Study subjects at higher risk for NCF were identified by characteristics known at enrollment or in early follow-up. Evaluation of follow-up in other trials might help determine whether the identified factors consistently correlate with retention.

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Published In

Int J Tuberc Lung Dis

DOI

EISSN

1815-7920

Publication Date

March 1, 2017

Volume

21

Issue

3

Start / End Page

286 / 296

Location

France

Related Subject Headings

  • Time Factors
  • Sex Factors
  • Risk Factors
  • Proportional Hazards Models
  • Multivariate Analysis
  • Microbiology
  • Medication Adherence
  • Male
  • Latent Tuberculosis
  • Isoniazid
 

Citation

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Chicago
ICMJE
MLA
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Moro, R. N., Sterling, T. R., Saukkonen, J., Vernon, A., Horsburgh, C. R., Chaisson, R. E., … Goldberg, S. (2017). Factors associated with non-completion of follow-up: 33-month latent tuberculous infection treatment trial. Int J Tuberc Lung Dis, 21(3), 286–296. https://doi.org/10.5588/ijtld.16.0469
Moro, R. N., T. R. Sterling, J. Saukkonen, A. Vernon, C. R. Horsburgh, R. E. Chaisson, C. D. Hamilton, M. E. Villarino, and S. Goldberg. “Factors associated with non-completion of follow-up: 33-month latent tuberculous infection treatment trial.Int J Tuberc Lung Dis 21, no. 3 (March 1, 2017): 286–96. https://doi.org/10.5588/ijtld.16.0469.
Moro RN, Sterling TR, Saukkonen J, Vernon A, Horsburgh CR, Chaisson RE, et al. Factors associated with non-completion of follow-up: 33-month latent tuberculous infection treatment trial. Int J Tuberc Lung Dis. 2017 Mar 1;21(3):286–96.
Moro, R. N., et al. “Factors associated with non-completion of follow-up: 33-month latent tuberculous infection treatment trial.Int J Tuberc Lung Dis, vol. 21, no. 3, Mar. 2017, pp. 286–96. Pubmed, doi:10.5588/ijtld.16.0469.
Moro RN, Sterling TR, Saukkonen J, Vernon A, Horsburgh CR, Chaisson RE, Hamilton CD, Villarino ME, Goldberg S. Factors associated with non-completion of follow-up: 33-month latent tuberculous infection treatment trial. Int J Tuberc Lung Dis. 2017 Mar 1;21(3):286–296.

Published In

Int J Tuberc Lung Dis

DOI

EISSN

1815-7920

Publication Date

March 1, 2017

Volume

21

Issue

3

Start / End Page

286 / 296

Location

France

Related Subject Headings

  • Time Factors
  • Sex Factors
  • Risk Factors
  • Proportional Hazards Models
  • Multivariate Analysis
  • Microbiology
  • Medication Adherence
  • Male
  • Latent Tuberculosis
  • Isoniazid