The Case for Adopting the "Species Complex" Nomenclature for the Etiologic Agents of Cryptococcosis.

Published online

Journal Article

Cryptococcosis is a potentially lethal disease of humans/animals caused by Cryptococcus neoformans and Cryptococcus gattii. Distinction between the two species is based on phenotypic and genotypic characteristics. Recently, it was proposed that C. neoformans be divided into two species and C. gattii into five species based on a phylogenetic analysis of 115 isolates. While this proposal adds to the knowledge about the genetic diversity and population structure of cryptococcosis agents, the published genotypes of 2,606 strains have already revealed more genetic diversity than is encompassed by seven species. Naming every clade as a separate species at this juncture will lead to continuing nomenclatural instability. In the absence of biological differences between clades and no consensus about how DNA sequence alone can delineate a species, we recommend using "Cryptococcus neoformans species complex" and "C. gattii species complex" as a practical intermediate step, rather than creating more species. This strategy recognizes genetic diversity without creating confusion.

Full Text

Duke Authors

Cited Authors

  • Kwon-Chung, KJ; Bennett, JE; Wickes, BL; Meyer, W; Cuomo, CA; Wollenburg, KR; Bicanic, TA; Castañeda, E; Chang, YC; Chen, J; Cogliati, M; Dromer, F; Ellis, D; Filler, SG; Fisher, MC; Harrison, TS; Holland, SM; Kohno, S; Kronstad, JW; Lazera, M; Levitz, SM; Lionakis, MS; May, RC; Ngamskulrongroj, P; Pappas, PG; Perfect, JR; Rickerts, V; Sorrell, TC; Walsh, TJ; Williamson, PR; Xu, J; Zelazny, AM; Casadevall, A

Published Date

  • January 2017

Published In

Volume / Issue

  • 2 / 1

PubMed ID

  • 28101535

Pubmed Central ID

  • 28101535

International Standard Serial Number (ISSN)

  • 2379-5042

Digital Object Identifier (DOI)

  • 10.1128/mSphere.00357-16

Language

  • eng

Conference Location

  • United States