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Providing lipid-based nutrient supplement during pregnancy does not reduce the risk of maternal P falciparum parasitaemia and reproductive tract infections: a randomised controlled trial.

Publication ,  Journal Article
Nkhoma, M; Ashorn, P; Ashorn, U; Dewey, KG; Gondwe, A; Mbotwa, J; Rogerson, S; Taylor, SM; Maleta, K
Published in: BMC Pregnancy Childbirth
January 17, 2017

BACKGROUND: Maternal infections are associated with maternal and foetal adverse outcomes. Nutrient supplementation during pregnancy may reduce the occurrence of infections by improving maternal immunity. We aimed to investigate the impact of small-quantity lipid-based nutrient supplement (SQ-LNS) on the occurrence of Plasmodium falciparum parasitaemia during pregnancy and trichomoniasis, vaginal candidiasis and urinary tract infection (UTI) after delivery. METHODS: Pregnant Malawian women enrolled in the iLiNS-DYAD trial receiving daily supplementation with SQ-LNS, multiple micronutrients (MMN) or iron & folic acid (IFA) from <20 gestation weeks (gw) were assessed for P. falciparum parasitaemia at 32 gw using rapid diagnostic testing (RDT), at 36 gw using polymerase chain reaction (PCR) and at delivery using both RDT and PCR; and at one week after delivery for trichomoniasis and vaginal candidiasis using wet mount microscopy and for UTI using urine dipstick analysis. The prevalence of each infection by intervention group was estimated at the prescribed time points and the global null hypothesis was tested using logistic regression. Adjusted analyses were performed using preselected covariates. RESULTS: The prevalence of P. falciparum parasitaemia was 10.7% at 32 gw, 9% at 36 gw, and 8.3% by RDT and 20.2% by PCR at delivery. After delivery the prevalence of trichomoniasis was 10.5%, vaginal candidiasis was 0.5%, and UTI was 3.1%. There were no differences between intervention groups in the prevalence of any of the infections. CONCLUSION: In this population, SQ-LNS did not influence the occurrence of maternal P. falciparum parasitaemia, trichomoniasis, vaginal candidiasis or UTI. TRIAL REGISTRATION: Identifier: NCT01239693 (10 November 2010).

Duke Scholars

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Published In

BMC Pregnancy Childbirth

DOI

EISSN

1471-2393

Publication Date

January 17, 2017

Volume

17

Issue

1

Start / End Page

35

Location

England

Related Subject Headings

  • Reproductive Tract Infections
  • Pregnancy Complications, Parasitic
  • Pregnancy Complications, Infectious
  • Pregnancy
  • Plasmodium falciparum
  • Parasitemia
  • Obstetrics & Reproductive Medicine
  • Micronutrients
  • Malaria, Falciparum
  • Lipids
 

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Nkhoma, M., Ashorn, P., Ashorn, U., Dewey, K. G., Gondwe, A., Mbotwa, J., … Maleta, K. (2017). Providing lipid-based nutrient supplement during pregnancy does not reduce the risk of maternal P falciparum parasitaemia and reproductive tract infections: a randomised controlled trial. BMC Pregnancy Childbirth, 17(1), 35. https://doi.org/10.1186/s12884-016-1215-2
Nkhoma, Minyanga, Per Ashorn, Ulla Ashorn, Kathryn G. Dewey, Austrida Gondwe, John Mbotwa, Stephen Rogerson, Steve M. Taylor, and Kenneth Maleta. “Providing lipid-based nutrient supplement during pregnancy does not reduce the risk of maternal P falciparum parasitaemia and reproductive tract infections: a randomised controlled trial.BMC Pregnancy Childbirth 17, no. 1 (January 17, 2017): 35. https://doi.org/10.1186/s12884-016-1215-2.
Nkhoma, Minyanga, et al. “Providing lipid-based nutrient supplement during pregnancy does not reduce the risk of maternal P falciparum parasitaemia and reproductive tract infections: a randomised controlled trial.BMC Pregnancy Childbirth, vol. 17, no. 1, Jan. 2017, p. 35. Pubmed, doi:10.1186/s12884-016-1215-2.
Nkhoma M, Ashorn P, Ashorn U, Dewey KG, Gondwe A, Mbotwa J, Rogerson S, Taylor SM, Maleta K. Providing lipid-based nutrient supplement during pregnancy does not reduce the risk of maternal P falciparum parasitaemia and reproductive tract infections: a randomised controlled trial. BMC Pregnancy Childbirth. 2017 Jan 17;17(1):35.
Journal cover image

Published In

BMC Pregnancy Childbirth

DOI

EISSN

1471-2393

Publication Date

January 17, 2017

Volume

17

Issue

1

Start / End Page

35

Location

England

Related Subject Headings

  • Reproductive Tract Infections
  • Pregnancy Complications, Parasitic
  • Pregnancy Complications, Infectious
  • Pregnancy
  • Plasmodium falciparum
  • Parasitemia
  • Obstetrics & Reproductive Medicine
  • Micronutrients
  • Malaria, Falciparum
  • Lipids