Association of in utero magnesium exposure and spontaneous intestinal perforations in extremely low birth weight infants.

Journal Article (Journal Article;Multicenter Study)

OBJECTIVE: The objective of this study is to determine whether antenatal exposure to magnesium is associated with spontaneous intestinal perforation (SIP) in extremely low birth weight (ELBW) infants (⩽1000 g). STUDY DESIGN: We identified all ELBW infants admitted to 1 of 323 neonatal intensive care units from 2007 to 2013. We used multivariable conditional logistic regression to compare outcomes in the first 21 days after birth between infants exposed and unexposed to magnesium in utero. RESULTS: Of the 28 035 infants, 11 789 (42%) were exposed to antenatal magnesium (AM). There was no difference in the risk of SIP, odds ratio=1.08 (95% confidence interval; 0.91 to 1.29), between infants exposed and unexposed to AM. Mortality in the first 21 days after birth was lower in the magnesium-exposed infants, odds ratio=0.76 (0.70 to 0.83). CONCLUSION: AM exposure in ELBW infants was not associated with increased risk of SIP.

Full Text

Duke Authors

Cited Authors

  • Downey, LC; Cotten, CM; Hornik, CP; Laughon, MM; Tolia, VN; Clark, RH; Smith, PB

Published Date

  • June 2017

Published In

Volume / Issue

  • 37 / 6

Start / End Page

  • 641 - 644

PubMed ID

  • 28125094

Pubmed Central ID

  • PMC5446291

Electronic International Standard Serial Number (EISSN)

  • 1476-5543

Digital Object Identifier (DOI)

  • 10.1038/jp.2016.274


  • eng

Conference Location

  • United States