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Distinctions in Breast Tumor Recurrence Patterns Post-Therapy among Racially Distinct Populations.

Publication ,  Journal Article
Wright, N; Xia, J; Cantuaria, G; Klimov, S; Jones, M; Neema, P; Il'yasova, D; Krishnamurti, U; Li, X; Reid, MD; Gupta, M; Rida, PCG; Osan, R; Aneja, R
Published in: PLoS One
2017

BACKGROUND: Clinical studies have revealed a higher risk of breast tumor recurrence in African-American (AA) patients compared to European-American (EA) patients, contributing to the alarming inequality in clinical outcomes among the ethnic groups. However, distinctions in recurrence patterns upon receiving hormone, radiation, and/or chemotherapy between the races remain poorly characterized. METHODS: We compared patterns and rates (per 1000 cancer patients per 1 year) of recurrence following each form of treatment between AA (n = 1850) and EA breast cancer patients (n = 7931) from a cohort of patients (n = 10504) treated between 2005-2015 at Northside Hospital in Atlanta, GA. RESULTS: Among patients who received any combination of adjuvant therapy, AA displayed higher overall rates of recurrence than EA (p = 0.015; HR: 1.699; CI: 1.108-2.606). Furthermore, recurrence rates were higher in AA than EA among stage I (p = 0.031; HR: 1.736; CI: 1.052-2.864) and T1 classified patients (p = 0.003; HR: 2.009; CI: 1.263-3.197). Interestingly, among patients who received neoadjuvant chemotherapy, AA displayed higher rates of local recurrence than EA (p = 0.024; HR: 7.134; CI: 1.295-39.313). CONCLUSION: Our analysis revealed higher incidence rates of recurrence in AA compared to EA among patients that received any combination of adjuvant therapy. Moreover, our data demonstrates an increased risk of tumor recurrence in AA than EA among patients diagnosed with minimally invasive disease. This is the first clinical study to suggest that neoadjuvant chemotherapy improves breast cancer recurrence rates and patterns in AA.

Duke Scholars

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Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2017

Volume

12

Issue

1

Start / End Page

e0170095

Location

United States

Related Subject Headings

  • White People
  • Survival Rate
  • Retrospective Studies
  • Prognosis
  • Neoplasm Staging
  • Neoplasm Recurrence, Local
  • Neoplasm Invasiveness
  • Neoplasm Grading
  • Middle Aged
  • Lymphatic Metastasis
 

Citation

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Chicago
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Wright, N., Xia, J., Cantuaria, G., Klimov, S., Jones, M., Neema, P., … Aneja, R. (2017). Distinctions in Breast Tumor Recurrence Patterns Post-Therapy among Racially Distinct Populations. PLoS One, 12(1), e0170095. https://doi.org/10.1371/journal.pone.0170095
Wright, Nikita, Jun Xia, Guilherme Cantuaria, Sergey Klimov, Mildred Jones, Pranay Neema, Dora Il’yasova, et al. “Distinctions in Breast Tumor Recurrence Patterns Post-Therapy among Racially Distinct Populations.PLoS One 12, no. 1 (2017): e0170095. https://doi.org/10.1371/journal.pone.0170095.
Wright N, Xia J, Cantuaria G, Klimov S, Jones M, Neema P, et al. Distinctions in Breast Tumor Recurrence Patterns Post-Therapy among Racially Distinct Populations. PLoS One. 2017;12(1):e0170095.
Wright, Nikita, et al. “Distinctions in Breast Tumor Recurrence Patterns Post-Therapy among Racially Distinct Populations.PLoS One, vol. 12, no. 1, 2017, p. e0170095. Pubmed, doi:10.1371/journal.pone.0170095.
Wright N, Xia J, Cantuaria G, Klimov S, Jones M, Neema P, Il’yasova D, Krishnamurti U, Li X, Reid MD, Gupta M, Rida PCG, Osan R, Aneja R. Distinctions in Breast Tumor Recurrence Patterns Post-Therapy among Racially Distinct Populations. PLoS One. 2017;12(1):e0170095.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2017

Volume

12

Issue

1

Start / End Page

e0170095

Location

United States

Related Subject Headings

  • White People
  • Survival Rate
  • Retrospective Studies
  • Prognosis
  • Neoplasm Staging
  • Neoplasm Recurrence, Local
  • Neoplasm Invasiveness
  • Neoplasm Grading
  • Middle Aged
  • Lymphatic Metastasis