Developing the Value Proposition for Personalized Medicine


Book Section

© 2017 Elsevier Inc. All rights reserved. Standard methodological approaches have successfully been applied to evaluate the cost-effectiveness of numerous personalized medicine tests, particularly for companion diagnostics developed in the context of a clinical trial. However, disagreement has emerged about the extent to which existing methods can characterize the value of personalized medicine. This chapter provides an overview of cost-effectiveness analysis and the factors determining the value of personalized medicine. The authors identify limitations of the traditional cost-effectiveness analysis framework and methodological issues that will arise with increasing use of multiple "omics" profiles to guide individualized selection of treatments.

Full Text

Duke Authors

Cited Authors

  • Reed, SD; Faulkner, E; Veenstra, DL

Published Date

  • December 15, 2016

Book Title

  • Genomic and Precision Medicine: Foundations, Translation, and Implementation: Third Edition

Start / End Page

  • 327 - 342

International Standard Book Number 13 (ISBN-13)

  • 9780128006818

Digital Object Identifier (DOI)

  • 10.1016/B978-0-12-800681-8.00022-0

Citation Source

  • Scopus