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ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis.

Publication ,  Journal Article
Saladi, SV; Ross, K; Karaayvaz, M; Tata, PR; Mou, H; Rajagopal, J; Ramaswamy, S; Ellisen, LW
Published in: Cancer Cell
January 9, 2017

Loss-of-function mutations in SWI/SNF chromatin-remodeling subunit genes are observed in many cancers, but an oncogenic role for SWI/SNF is not well established. Here, we reveal that ACTL6A, encoding an SWI/SNF subunit linked to stem cell and progenitor cell function, is frequently co-amplified and highly expressed together with the p53 family member p63 in head and neck squamous cell carcinoma (HNSCC). ACTL6A and p63 physically interact, cooperatively controlling a transcriptional program that promotes proliferation and suppresses differentiation, in part through activation of the Hippo-YAP pathway via regulators including WWC1. Ectopic ACTL6A/p63 expression promotes tumorigenesis, while ACTL6A expression and YAP activation are highly correlated in primary HNSCC and predict poor patient survival. Thus, ACTL6A and p63 collaborate as oncogenic drivers in HNSCC.

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Published In

Cancer Cell

DOI

EISSN

1878-3686

Publication Date

January 9, 2017

Volume

31

Issue

1

Start / End Page

35 / 49

Location

United States

Related Subject Headings

  • YAP-Signaling Proteins
  • Transcriptome
  • Transcription Factors
  • Squamous Cell Carcinoma of Head and Neck
  • Protein Serine-Threonine Kinases
  • Prognosis
  • Phosphoproteins
  • Oncology & Carcinogenesis
  • Mice
  • Membrane Proteins
 

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Saladi, S. V., Ross, K., Karaayvaz, M., Tata, P. R., Mou, H., Rajagopal, J., … Ellisen, L. W. (2017). ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis. Cancer Cell, 31(1), 35–49. https://doi.org/10.1016/j.ccell.2016.12.001
Saladi, Srinivas Vinod, Kenneth Ross, Mihriban Karaayvaz, Purushothama R. Tata, Hongmei Mou, Jayaraj Rajagopal, Sridhar Ramaswamy, and Leif W. Ellisen. “ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis.Cancer Cell 31, no. 1 (January 9, 2017): 35–49. https://doi.org/10.1016/j.ccell.2016.12.001.
Saladi SV, Ross K, Karaayvaz M, Tata PR, Mou H, Rajagopal J, et al. ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis. Cancer Cell. 2017 Jan 9;31(1):35–49.
Saladi, Srinivas Vinod, et al. “ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis.Cancer Cell, vol. 31, no. 1, Jan. 2017, pp. 35–49. Pubmed, doi:10.1016/j.ccell.2016.12.001.
Saladi SV, Ross K, Karaayvaz M, Tata PR, Mou H, Rajagopal J, Ramaswamy S, Ellisen LW. ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis. Cancer Cell. 2017 Jan 9;31(1):35–49.
Journal cover image

Published In

Cancer Cell

DOI

EISSN

1878-3686

Publication Date

January 9, 2017

Volume

31

Issue

1

Start / End Page

35 / 49

Location

United States

Related Subject Headings

  • YAP-Signaling Proteins
  • Transcriptome
  • Transcription Factors
  • Squamous Cell Carcinoma of Head and Neck
  • Protein Serine-Threonine Kinases
  • Prognosis
  • Phosphoproteins
  • Oncology & Carcinogenesis
  • Mice
  • Membrane Proteins