Nanoparticles for photoacoustic imaging of vasculature


Book Section

© Springer International Publishing Switzerland 2017. Photoacoustic imaging (PAI) is a multi-scale, multi-contrast biomedical imaging modality that can provide anatomical, functional, metabolic, and molecular information about tissue. PAI offers up to submicron resolution and several centimeters penetration depth, employing various endogenous or exogenous contrasts. In particular, because nanoparticles strongly absorb near infrared light, they enable high-contrast PAI with improved detection sensitivity at depths. In this chapter, we review the use of nanoparticles to enhance the performance of PAI in a wide range of biomedical applications, in particular in imaging vasculature. By using engineered nanoparticles with different structures and functions, PAI can target specific molecules in disease associated endothelial cells. By manipulating nanoparticles with light or ultrasound, PAI can also guide therapy. Overall, nanoparticle-enhanced PAI shows promising potential for high-sensitivity, deep-tissue imaging, especially for vasculature imaging.

Full Text

Duke Authors

Cited Authors

  • Zhou, M; Li, L; Yao, J; Bouchard, RR; Wang, LV; Li, C

Published Date

  • January 1, 2016

Book Title

  • Design and Applications of Nanoparticles in Biomedical Imaging

Start / End Page

  • 337 - 356

International Standard Book Number 13 (ISBN-13)

  • 9783319421674

Digital Object Identifier (DOI)

  • 10.1007/978-3-319-42169-8_16

Citation Source

  • Scopus