A U-shaped Association Between Blood Pressure and Cognitive Impairment in Chinese Elderly.

Journal Article (Journal Article)

OBJECTIVES: Higher or lower blood pressure may relate to cognitive impairment, whereas the relationship between blood pressure and cognitive impairment among the elderly is not well-studied. The study objective was to determine whether blood pressure is associated with cognitive impairment in the elderly, and, if so, to accurately describe the association. DESIGN: Cross-sectional data from the sixth wave of the Chinese Longitudinal Healthy Longevity Survey (CLHLS) conducted in 2011. SETTING: Community-based setting in longevity areas in China. PARTICIPANTS: A total of 7144 Chinese elderly aged 65 years and older were included in the sample. MEASURES: Systolic blood pressures (SBP) and diastolic blood pressures (DBP) were measured, pulse pressure (PP) was calculated as (SBP) - (DBP) and mean arterial pressures (MAP) was calculated as 1/3(SBP) + 2/3(DBP). Cognitive function was assessed via a validated Mini-Mental State Examination (MMSE). RESULTS: Based on the results of generalized additive models (GAMs), U-shaped associations were identified between cognitive impairment and SBP, DBP, PP, and MAP. The cutpoints at which risk for cognitive impairment (MMSE <24) was minimized were determined by quadratic models as 141 mm Hg, 85 mm Hg, 62 mm Hg, and 103 mm Hg, respectively. In the logistic models, U-shaped associations remained for SBP, DBP, and MAP but not PP. Below the identified cutpoints, each 1-mm Hg decrease in blood pressure corresponded to 0.7%, 1.1%, and 1.1% greater risk in the risk of cognitive impairment, respectively. Above the cutpoints, each 1-mm Hg increase in blood pressure corresponded to 1.2%, 1.8%, and 2.1% greater risk of cognitive impairment for SBP, DBP, and MAP, respectively. CONCLUSION: A U-shaped association between blood pressure and cognitive function in an elderly Chinese population was found. Recognition of these instances is important in identifying the high-risk population for cognitive impairment and to individualize blood pressure management for cognitive impairment prevention.

Full Text

Duke Authors

Cited Authors

  • Lv, Y-B; Zhu, P-F; Yin, Z-X; Kraus, VB; Threapleton, D; Chei, C-L; Brasher, MS; Zhang, J; Qian, H-Z; Mao, C; Matchar, DB; Luo, J-S; Zeng, Y; Shi, X-M

Published Date

  • February 1, 2017

Published In

Volume / Issue

  • 18 / 2

Start / End Page

  • 193.e7 - 193.e13

PubMed ID

  • 28126139

Pubmed Central ID

  • PMC5294228

Electronic International Standard Serial Number (EISSN)

  • 1538-9375

Digital Object Identifier (DOI)

  • 10.1016/j.jamda.2016.11.011


  • eng

Conference Location

  • United States