Resistance diagnosis and the changing epidemiology of antibiotic resistance.

Journal Article (Review;Journal Article)

Widespread adoption of point-of-care resistance diagnostics (POCRD) reduces ineffective antibiotic use but could increase overall antibiotic use. Indeed, in the context of a standard susceptible-infected epidemiological model with a single antibiotic, POCRD accelerates the rise of resistance in the disease-causing bacterial population. When multiple antibiotics are available, however, POCRD may slow the rise of resistance even as more patients receive antibiotic treatment, belying the conventional wisdom that antibiotics are "exhaustible resources" whose increased use necessarily promotes the rise of resistance.

Full Text

Duke Authors

Cited Authors

  • McAdams, D

Published Date

  • January 2017

Published In

Volume / Issue

  • 1388 / 1

Start / End Page

  • 5 - 17

PubMed ID

  • 28134444

Electronic International Standard Serial Number (EISSN)

  • 1749-6632

International Standard Serial Number (ISSN)

  • 0077-8923

Digital Object Identifier (DOI)

  • 10.1111/nyas.13300


  • eng