Serelaxin in acute heart failure patients with and without atrial fibrillation: a secondary analysis of the RELAX-AHF trial.


Journal Article

Atrial fibrillation (AFib) is a common comorbidity in HF and affects patients' outcome. We sought to assess the effects of serelaxin in patients with and without AFib.In a post hoc analysis of the RELAX-AHF trial, we compared the effects of serelaxin on efficacy end points, safety end points and biomarkers in 1161 patients with and without AFib on admission electrocardiogram.AFib was present in 41.3% of patients. Serelaxin had a similar effect in patients with and without AFib, including dyspnea relief by visual analog scale through day 5 [mean change in area under the curve, 541.11 (33.79, 1048.44), p = 0.0366 in AFib versus 361.80 (-63.30, 786.90), p = 0.0953 in non-AFib, interaction p = 0.5954] and all-cause death through day 180 [HR = 0.42 (0.23, 0.77), p = 0.0051 in AFib versus 0.90 (0.53, 1.52), p = 0.6888 in non-AFib, interaction p = 0.0643]. Serelaxin was similarly safe in the two groups and induced similar reductions in biomarkers of cardiac, renal and hepatic damage. Stroke occurred more frequently in AFib patients (2.8 vs. 0.8%, p = 0.0116) and there was a trend for lower stroke incidence in the serelaxin arm in AFib patients (odds ratios, 0.31, p = 0.0759 versus 3.88, p = 0.2255 in non-AFib, interaction p = 0.0518).Serelaxin was similarly safe and efficacious in improving short- and long-term outcomes and inducing organ protection in acute HF patients with and without AFib.

Full Text

Duke Authors

Cited Authors

  • Filippatos, G; Farmakis, D; Metra, M; Cotter, G; Davison, BA; Felker, GM; Greenberg, BH; Hua, TA; Pang, PS; Ponikowski, P; Qian, M; Severin, TA; Voors, AA; Teerlink, JR

Published Date

  • June 2017

Published In

Volume / Issue

  • 106 / 6

Start / End Page

  • 444 - 456

PubMed ID

  • 28150186

Pubmed Central ID

  • 28150186

Electronic International Standard Serial Number (EISSN)

  • 1861-0692

International Standard Serial Number (ISSN)

  • 1861-0684

Digital Object Identifier (DOI)

  • 10.1007/s00392-016-1074-x


  • eng