Redirecting cardiac growth mechanisms for therapeutic regeneration.

Published

Journal Article (Review)

Heart failure is a major source of morbidity and mortality. Replacing lost myocardium with new tissue is a major goal of regenerative medicine. Unlike adult mammals, zebrafish and neonatal mice are capable of heart regeneration following cardiac injury. In both contexts, the regenerative program echoes molecular and cellular events that occur during cardiac development and morphogenesis, notably muscle creation through division of cardiomyocytes. Based on studies over the past decade, it is now accepted that the adult mammalian heart undergoes a low grade of cardiomyocyte turnover. Recent data suggest that this cardiomyocyte turnover can be augmented in the adult mammalian heart by redeployment of developmental factors. These findings and others suggest that stimulating endogenous regenerative responses can emerge as a therapeutic strategy for human cardiovascular disease.

Full Text

Duke Authors

Cited Authors

  • Karra, R; Poss, KD

Published Date

  • February 2017

Published In

Volume / Issue

  • 127 / 2

Start / End Page

  • 427 - 436

PubMed ID

  • 28145902

Pubmed Central ID

  • 28145902

Electronic International Standard Serial Number (EISSN)

  • 1558-8238

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/JCI89786

Language

  • eng