Host controls of HIV broadly neutralizing antibody development.

Journal Article (Journal Article;Review)

Induction of broadly neutralizing antibodies (bNAbs) is a major goal of HIV vaccine development. BNAbs are made during HIV infection by a subset of individuals but currently cannot be induced in the setting of vaccination. Considerable progress has been made recently in understanding host immunologic controls of bNAb induction and maturation in the setting of HIV infection, and point to key roles for both central and peripheral immunologic tolerance mechanisms in limiting bnAb development. Immune tolerance checkpoint inhibition has been transformative in promotion of anti-tumor CD8 T-cell responses in the treatment of certain malignancies. Here, we review the evidence for host controls of bNAb responses, and discuss strategies for the transient modulation of immune responses with vaccines toward the goal of enhancing germinal center B-cell responses to favor bNAb B-cell lineages and to foster their maturation to full neutralization potency.

Full Text

Duke Authors

Cited Authors

  • Kelsoe, G; Haynes, BF

Published Date

  • January 2017

Published In

Volume / Issue

  • 275 / 1

Start / End Page

  • 79 - 88

PubMed ID

  • 28133807

Pubmed Central ID

  • PMC5479487

Electronic International Standard Serial Number (EISSN)

  • 1600-065X

Digital Object Identifier (DOI)

  • 10.1111/imr.12508


  • eng

Conference Location

  • England