Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases.

Journal Article (Journal Article;Review)

The coenzyme nicotinamide adenine dinucleotide (NAD+) has key roles in the regulation of redox status and energy metabolism. NAD+ depletion is emerging as a major contributor to the pathogenesis of cardiac and renal diseases and NAD+ repletion strategies have shown therapeutic potential as a means to restore healthy metabolism and physiological function. The pleotropic roles of NAD+ enable several possible avenues by which repletion of this coenzyme could have therapeutic efficacy. In particular, NAD+ functions as a co-substrate in deacylation reactions carried out by the sirtuin family of enzymes. These NAD+-dependent deacylases control several aspects of metabolism and a wealth of data suggests that boosting sirtuin activity via NAD+ supplementation might be a promising therapy for cardiac and renal pathologies. This Review summarizes the role of NAD+ metabolism in the heart and kidney, and highlights the mitochondrial sirtuins as mediators of some of the beneficial effects of NAD+-boosting therapies in preclinical animal models. We surmise that modulating the NAD+-sirtuin axis is a clinically relevant approach to develop new therapies for cardiac and renal diseases.

Full Text

Duke Authors

Cited Authors

  • Hershberger, KA; Martin, AS; Hirschey, MD

Published Date

  • April 2017

Published In

Volume / Issue

  • 13 / 4

Start / End Page

  • 213 - 225

PubMed ID

  • 28163307

Pubmed Central ID

  • PMC5508210

Electronic International Standard Serial Number (EISSN)

  • 1759-507X

Digital Object Identifier (DOI)

  • 10.1038/nrneph.2017.5


  • eng

Conference Location

  • England