The ompU Paralogue vca1008 is required for virulence of Vibrio cholerae.

Journal Article (Journal Article)

We made single and combined mutations in ompU, ompT, and the two putative porin genes vca1008 and vc0972. The fitness of the strains was tested in vitro and in the infant mouse model of intestinal infection. We also studied the transcriptional induction of vca1008 in vitro and during mouse infection. We show that vca1008 is induced during infection and is necessary and sufficient (in the absence of ompU, ompT, and vc0972) for infection.

Full Text

Duke Authors

Cited Authors

  • Osorio, CG; Martinez-Wilson, H; Camilli, A

Published Date

  • August 2004

Published In

Volume / Issue

  • 186 / 15

Start / End Page

  • 5167 - 5171

PubMed ID

  • 15262955

Pubmed Central ID

  • PMC451605

International Standard Serial Number (ISSN)

  • 0021-9193

Digital Object Identifier (DOI)

  • 10.1128/JB.186.15.5167-5171.2004


  • eng

Conference Location

  • United States