Atypical tubule hyperplasia and renal tubule tumors in conventional rats on 90-day toxicity studies.
Journal Article (Journal Article;Multicenter Study)
Bilateral, multicentric renal tubule tumors were found in 4 rats at the termination of 3 separate 90-day toxicity studies during the safety evaluation of 3 unrelated chemicals. The 3 studies were conducted at 2 separate locations, but the rats used were obtained from the same commercial source. The rat strains were Fischer-344 (1 male and 1 female case) and Sprague-Dawley (2 female cases). Three of the renal tumor cases were from either the high-dose or mid-dose treatment groups, and 1 case was an untreated control. The tumors were accompanied by multiple foci of atypical tubule hyperplasia but only in the tumor-bearing rats. There were no lesions associated with renal tumor pathogenesis in any of the remaining treated or untreated animals in the 3 studies. In addition, there was no indication of nephrotoxicity in the treated or untreated animals. Tumor morphology was characterized by a generally vacuolated appearance, eosinophilia, cytoplasmic and nuclear pleomorphism, and conspicuously hypertrophied nucleoli. The renal tubule tumors in these 90-day studies were compared to hereditary renal tubule tumors occurring in the Eker rat, a Long-Evans derivative with a genetic predisposition to this tumor type. The multiplicity of renal tubule tumors, early age of onset, and tumor morphology described in the cases from the 90-day studies were very similar to those characterizing the hereditary renal tumor model.(ABSTRACT TRUNCATED AT 250 WORDS)
Full Text
Duke Authors
Cited Authors
- Hard, GC; Long, PH; Crissman, JW; Everitt, JI; Yano, BL; Bertram, TA
Published Date
- 1994
Published In
Volume / Issue
- 22 / 5
Start / End Page
- 489 - 496
PubMed ID
- 7899777
International Standard Serial Number (ISSN)
- 0192-6233
Digital Object Identifier (DOI)
- 10.1177/019262339402200503
Language
- eng
Conference Location
- United States