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Activity level, apoptosis, and development of cachexia in Apc(Min/+) mice.

Publication ,  Journal Article
Baltgalvis, KA; Berger, FG; Peña, MMO; Mark Davis, J; White, JP; Carson, JA
Published in: J Appl Physiol (1985)
October 2010

Criteria for diagnosing cachexia in adults include unintentional loss in body weight, decreased strength, fatigue, anorexia, and low muscle mass. Cachexia is also associated with systemic inflammation, altered metabolism, and anemia. The Apc(Min/+) mouse is a model of cachexia directly related to intestinal tumor burden and subsequent chronic inflammation. These mice also demonstrate muscle weakness, fatigue, decreased volitional activity, and elevated circulating IL-6 levels. The purpose of this study was to determine the time course of changes in physical activity and their relationship to anemia, muscle apoptosis, and muscle mass and body mass loss during cachexia. A subset of male Apc(Min/+) mice were given access to voluntary activity wheels from 5 to 26 wk of age, while sedentary male Apc(Min/+) mice were housed in cages lacking wheels. At the study's end mice were stratified by cachectic symptoms. Severely cachectic mice had decreased wheel running performance at 15 wk of age, while anemia and body weight loss were not present until 18 wk of age. Severely cachectic mice had lower hemoglobin levels compared with mildly cachectic mice at 13, 18, and 22 wk of age. Severely cachectic mice also demonstrated threefold more BCL2-associated X protein (BAX) protein in the gastrocnemius muscle at 26 wk of age compared with mildly cachectic mice. In sedentary Apc(Min/+) mice at 26 wk of age anemia was present, and markers of apoptosis were induced in severely cachectic muscle. Proapoptotic protein expression was induced in both red and white portions of gastrocnemius muscle as well as in soleus muscle of severely cachectic mice compared with mildly cachectic mice. These data demonstrate that decrements in wheel running performance precede loss of body mass and that inherent muscle oxidative capacity is not protective against muscle apoptosis.

Duke Scholars

Published In

J Appl Physiol (1985)

DOI

EISSN

1522-1601

Publication Date

October 2010

Volume

109

Issue

4

Start / End Page

1155 / 1161

Location

United States

Related Subject Headings

  • bcl-2-Associated X Protein
  • Weight Loss
  • Time Factors
  • Severity of Illness Index
  • Running
  • Physiology
  • Phenotype
  • Oxidation-Reduction
  • Mutation
  • Muscle, Skeletal
 

Citation

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Baltgalvis, K. A., Berger, F. G., Peña, M. M. O., Mark Davis, J., White, J. P., & Carson, J. A. (2010). Activity level, apoptosis, and development of cachexia in Apc(Min/+) mice. J Appl Physiol (1985), 109(4), 1155–1161. https://doi.org/10.1152/japplphysiol.00442.2010
Baltgalvis, Kristen A., Franklin G. Berger, Maria Marjorette O. Peña, J. Mark Davis, James P. White, and James A. Carson. “Activity level, apoptosis, and development of cachexia in Apc(Min/+) mice.J Appl Physiol (1985) 109, no. 4 (October 2010): 1155–61. https://doi.org/10.1152/japplphysiol.00442.2010.
Baltgalvis KA, Berger FG, Peña MMO, Mark Davis J, White JP, Carson JA. Activity level, apoptosis, and development of cachexia in Apc(Min/+) mice. J Appl Physiol (1985). 2010 Oct;109(4):1155–61.
Baltgalvis, Kristen A., et al. “Activity level, apoptosis, and development of cachexia in Apc(Min/+) mice.J Appl Physiol (1985), vol. 109, no. 4, Oct. 2010, pp. 1155–61. Pubmed, doi:10.1152/japplphysiol.00442.2010.
Baltgalvis KA, Berger FG, Peña MMO, Mark Davis J, White JP, Carson JA. Activity level, apoptosis, and development of cachexia in Apc(Min/+) mice. J Appl Physiol (1985). 2010 Oct;109(4):1155–1161.

Published In

J Appl Physiol (1985)

DOI

EISSN

1522-1601

Publication Date

October 2010

Volume

109

Issue

4

Start / End Page

1155 / 1161

Location

United States

Related Subject Headings

  • bcl-2-Associated X Protein
  • Weight Loss
  • Time Factors
  • Severity of Illness Index
  • Running
  • Physiology
  • Phenotype
  • Oxidation-Reduction
  • Mutation
  • Muscle, Skeletal