Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.
Publication
, Journal Article
Postmus, I; Trompet, S; Deshmukh, HA; Barnes, MR; Li, X; Warren, HR; Chasman, DI; Zhou, K; Arsenault, BJ; Donnelly, LA; Wiggins, KL; Avery, CL ...
Published in: Nat Commun
October 28, 2014
Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects. We validate the most promising signals in a further 22,318 statin recipients and identify two loci, SORT1/CELSR2/PSRC1 and SLCO1B1, not previously identified in GWAS. Moreover, we confirm the previously described associations with APOE and LPA. Our findings advance the understanding of the pharmacogenetic architecture of statin response.
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Published In
Nat Commun
DOI
EISSN
2041-1723
Publication Date
October 28, 2014
Volume
5
Start / End Page
5068
Location
England
Related Subject Headings
- Polymorphism, Single Nucleotide
- Pharmacogenetics
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Humans
- Genome-Wide Association Study
- Cholesterol, LDL
Citation
APA
Chicago
ICMJE
MLA
NLM
Postmus, I., Trompet, S., Deshmukh, H. A., Barnes, M. R., Li, X., Warren, H. R., … Caulfield, M. J. (2014). Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. Nat Commun, 5, 5068. https://doi.org/10.1038/ncomms6068
Postmus, Iris, Stella Trompet, Harshal A. Deshmukh, Michael R. Barnes, Xiaohui Li, Helen R. Warren, Daniel I. Chasman, et al. “Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.” Nat Commun 5 (October 28, 2014): 5068. https://doi.org/10.1038/ncomms6068.
Postmus I, Trompet S, Deshmukh HA, Barnes MR, Li X, Warren HR, et al. Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. Nat Commun. 2014 Oct 28;5:5068.
Postmus, Iris, et al. “Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.” Nat Commun, vol. 5, Oct. 2014, p. 5068. Pubmed, doi:10.1038/ncomms6068.
Postmus I, Trompet S, Deshmukh HA, Barnes MR, Li X, Warren HR, Chasman DI, Zhou K, Arsenault BJ, Donnelly LA, Wiggins KL, Avery CL, Griffin P, Feng Q, Taylor KD, Li G, Evans DS, Smith AV, de Keyser CE, Johnson AD, de Craen AJM, Stott DJ, Buckley BM, Ford I, Westendorp RGJ, Slagboom PE, Sattar N, Munroe PB, Sever P, Poulter N, Stanton A, Shields DC, O’Brien E, Shaw-Hawkins S, Chen Y-DI, Nickerson DA, Smith JD, Dubé MP, Boekholdt SM, Hovingh GK, Kastelein JJP, McKeigue PM, Betteridge J, Neil A, Durrington PN, Doney A, Carr F, Morris A, McCarthy MI, Groop L, Ahlqvist E, Welcome Trust Case Control Consortium, Bis JC, Rice K, Smith NL, Lumley T, Whitsel EA, Stürmer T, Boerwinkle E, Ngwa JS, O’Donnell CJ, Vasan RS, Wei W-Q, Wilke RA, Liu C-T, Sun F, Guo X, Heckbert SR, Post W, Sotoodehnia N, Arnold AM, Stafford JM, Ding J, Herrington DM, Kritchevsky SB, Eiriksdottir G, Launer LJ, Harris TB, Chu AY, Giulianini F, MacFadyen JG, Barratt BJ, Nyberg F, Stricker BH, Uitterlinden AG, Hofman A, Rivadeneira F, Emilsson V, Franco OH, Ridker PM, Gudnason V, Liu Y, Denny JC, Ballantyne CM, Rotter JI, Adrienne Cupples L, Psaty BM, Palmer CNA, Tardif J-C, Colhoun HM, Hitman G, Krauss RM, Wouter Jukema J, Caulfield MJ. Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. Nat Commun. 2014 Oct 28;5:5068.
Published In
Nat Commun
DOI
EISSN
2041-1723
Publication Date
October 28, 2014
Volume
5
Start / End Page
5068
Location
England
Related Subject Headings
- Polymorphism, Single Nucleotide
- Pharmacogenetics
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Humans
- Genome-Wide Association Study
- Cholesterol, LDL