Allogeneic Hematopoietic Cell Transplantation for Aggressive NK Cell Leukemia. A Center for International Blood and Marrow Transplant Research Analysis.

Journal Article (Journal Article;Multicenter Study)

Aggressive NK cell leukemia (ANKL) is an exceedingly rare form of leukemia and carries a poor prognosis, with a median survival of only 2 months. Using the Center for International Blood and Marrow Transplant Research database, we evaluated outcomes of allogeneic hematopoietic cell transplantation (alloHCT) in patients with ANKL. Twenty-one patients with a centrally confirmed diagnosis of ANKL were included. Median patient age was 42 years and 15 patients (71%) were Caucasian. Fourteen patients (67%) were in complete remission (CR) at the time of alloHCT, and 5 patients had active disease. Median follow-up of survivors was 25 months (range, 12 to 116). The 2-year estimates of nonrelapse mortality, relapse/progression, progression-free (PFS), and overall survival (OS) were 21%, 59%, 20%, and 24%, respectively. The 2-year PFS of patients in CR at the time of alloHCT was significantly better than that of patients with active disease at transplantation (30% versus 0%; P = .001). The 2-year OS in similar order was 38% versus 0% (P < .001). In conclusion, this registry analysis that included majority non-Asian patient population shows that alloHCT can provide durable disease control in a subset of ANKL patients. Achieving CR before transplantation appears to be a prerequisite for successful transplantation outcomes.

Full Text

Duke Authors

Cited Authors

  • Hamadani, M; Kanate, AS; DiGilio, A; Ahn, KW; Smith, SM; Lee, JW; Ayala, E; Chao, N; Hari, P; Bolaños-Meade, J; Gress, R; Smedegaard Anderson, N; Chen, Y-B; Farooq, U; Schiller, G; Yared, J; Sureda, A; Fenske, TS; Olteanu, H

Published Date

  • May 2017

Published In

Volume / Issue

  • 23 / 5

Start / End Page

  • 853 - 856

PubMed ID

  • 28161608

Pubmed Central ID

  • PMC5410937

Electronic International Standard Serial Number (EISSN)

  • 1523-6536

Digital Object Identifier (DOI)

  • 10.1016/j.bbmt.2017.01.082


  • eng

Conference Location

  • United States