Metabolomics: A Primer.

Journal Article (Journal Article;Review)

Metabolomics generates a profile of small molecules that are derived from cellular metabolism and can directly reflect the outcome of complex networks of biochemical reactions, thus providing insights into multiple aspects of cellular physiology. Technological advances have enabled rapid and increasingly expansive data acquisition with samples as small as single cells; however, substantial challenges in the field remain. In this primer we provide an overview of metabolomics, especially mass spectrometry (MS)-based metabolomics, which uses liquid chromatography (LC) for separation, and discuss its utilities and limitations. We identify and discuss several areas at the frontier of metabolomics. Our goal is to give the reader a sense of what might be accomplished when conducting a metabolomics experiment, now and in the near future.

Full Text

Duke Authors

Cited Authors

  • Liu, X; Locasale, JW

Published Date

  • April 2017

Published In

Volume / Issue

  • 42 / 4

Start / End Page

  • 274 - 284

PubMed ID

  • 28196646

Pubmed Central ID

  • PMC5376220

International Standard Serial Number (ISSN)

  • 0968-0004

Digital Object Identifier (DOI)

  • 10.1016/j.tibs.2017.01.004


  • eng

Conference Location

  • England