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Models of toxicity of diacetyl and alternative diones.

Publication ,  Journal Article
Brass, DM; Palmer, SM
Published in: Toxicology
August 1, 2017

Diacetyl (DA; 2,3-butanedione), with the chemical formula (CH3CO)2 is a volatile organic compound with a deep yellow color and a strong buttery flavor and aroma. These properties have made DA a particularly useful and common food flavoring ingredient. However, because of this increased occupational use, workers can be exposed to high vapor concentrations in the workplace. Despite being listed by the USFDA to be 'generally regarded as safe' (GRAS), multiple lines of evidence suggest that exposure to high concentrations of DA vapor causes long-term impairments in lung function with lung function testing indicating evidence of either restrictive or obstructive airway narrowing in affected individuals. A growing number of pre-clinical studies have now addressed the short and long-term toxicity associated with DA exposure providing further insight into the toxicity of DA and related diones. This review summarizes these observations.

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Published In

Toxicology

DOI

EISSN

1879-3185

Publication Date

August 1, 2017

Volume

388

Start / End Page

15 / 20

Location

Ireland

Related Subject Headings

  • Toxicology
  • Time Factors
  • Respiratory Function Tests
  • Occupational Exposure
  • Occupational Diseases
  • Lung Diseases
  • Inhalation Exposure
  • Humans
  • Flavoring Agents
  • Diacetyl
 

Citation

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Brass, D. M., & Palmer, S. M. (2017). Models of toxicity of diacetyl and alternative diones. Toxicology, 388, 15–20. https://doi.org/10.1016/j.tox.2017.02.011
Brass, David M., and Scott M. Palmer. “Models of toxicity of diacetyl and alternative diones.Toxicology 388 (August 1, 2017): 15–20. https://doi.org/10.1016/j.tox.2017.02.011.
Brass DM, Palmer SM. Models of toxicity of diacetyl and alternative diones. Toxicology. 2017 Aug 1;388:15–20.
Brass, David M., and Scott M. Palmer. “Models of toxicity of diacetyl and alternative diones.Toxicology, vol. 388, Aug. 2017, pp. 15–20. Pubmed, doi:10.1016/j.tox.2017.02.011.
Brass DM, Palmer SM. Models of toxicity of diacetyl and alternative diones. Toxicology. 2017 Aug 1;388:15–20.
Journal cover image

Published In

Toxicology

DOI

EISSN

1879-3185

Publication Date

August 1, 2017

Volume

388

Start / End Page

15 / 20

Location

Ireland

Related Subject Headings

  • Toxicology
  • Time Factors
  • Respiratory Function Tests
  • Occupational Exposure
  • Occupational Diseases
  • Lung Diseases
  • Inhalation Exposure
  • Humans
  • Flavoring Agents
  • Diacetyl