Miniature spectral imaging device for wide-field quantitative functional imaging of the morphological landscape of breast tumor margins.
Published
Journal Article
We have developed a portable, breast margin assessment probe leveraging diffuse optical spectroscopy to quantify the morphological landscape of breast tumor margins during breast conserving surgery. The approach presented here leverages a custom-made 16-channel annular photodiode imaging array (arranged in a 4 × 4 grid), a raster-scanning imaging platform with precision pressure control, and compressive sensing with an optimized set of eight wavelengths in the visible spectral range. A scalable Monte-Carlo-based inverse model is used to generate optical property [ ? s ? ( ? ) and ? a ( ? ) ] measures for each of the 16 simultaneously captured diffuse reflectance spectra. Subpixel sampling (0.75 mm) is achieved through incremental x , y raster scanning of the imaging probe, providing detailed optical parameter maps of breast margins over a 2 × 2 ?? cm 2 area in ? 9 ?? min . The morphological landscape of a tumor margin is characterized using optical surrogates for the fat to fibroglandular content ratio, which has demonstrated diagnostic utility in delineating tissue subtypes in the breast.
Full Text
Duke Authors
- Brooke, Martin A.
- Geradts, Joseph
- Greenup, Rachel Adams
- Jokerst, Nan Marie
- Palmer, Gregory M.
- Ramanujam, Nimmi
Cited Authors
- Nichols, BS; Llopis, A; Palmer, GM; McCachren, SS; Senlik, O; Miller, D; Brooke, MA; Jokerst, NM; Geradts, J; Greenup, R; Ramanujam, N
Published Date
- February 1, 2017
Published In
Volume / Issue
- 22 / 2
Start / End Page
- 26007 -
PubMed ID
- 28241273
Pubmed Central ID
- 28241273
Electronic International Standard Serial Number (EISSN)
- 1560-2281
Digital Object Identifier (DOI)
- 10.1117/1.JBO.22.2.026007
Language
- eng
Conference Location
- United States