Glutamine Metabolism in Cancer: Understanding the Heterogeneity.


Journal Article (Review)

Reliance on glutamine has long been considered a hallmark of cancer cell metabolism. However, some recent studies have challenged this notion in vivo, prompting a need for further clarifications on the role of glutamine metabolism in cancer. We find that there is ample evidence of an essential role for glutamine in tumors and that a variety of factors, including tissue type, the underlying cancer genetics, the tumor microenvironment and other variables such as diet and host physiology collectively influence the role of glutamine in cancer. Thus the requirements for glutamine in cancer are overall highly heterogeneous. In this review, we discuss the implications both for basic science and for targeting glutamine metabolism in cancer therapy.

Full Text

Duke Authors

Cited Authors

  • Cluntun, AA; Lukey, MJ; Cerione, RA; Locasale, JW

Published Date

  • March 2017

Published In

Volume / Issue

  • 3 / 3

Start / End Page

  • 169 - 180

PubMed ID

  • 28393116

Pubmed Central ID

  • 28393116

International Standard Serial Number (ISSN)

  • 2405-8033

Digital Object Identifier (DOI)

  • 10.1016/j.trecan.2017.01.005


  • eng

Conference Location

  • United States