Clinical and neurological abnormalities in adult celiac disease.


Journal Article

We assessed the occurrence of neurological signs and symptoms in adult patients with celiac disease and evaluated the correlation between neurological features and diet. A total of 176 patients and 52 age-matched controls underwent a semistructural interview and a neurologic examination. The effect of gluten-free diet was evaluated by comparing the prevalence of signs and symptoms among patients adhering to a gluten-free diet and patients on an unrestricted diet. The occurrence of headache, dysthymia and signs of peripheral neuropathy was significantly higher in patients with celiac disease than in control subjects. Adherence to a strict gluten-free diet was associated with a significant reduction of headache, dysthymia, cramps and weakness, but did not modify the occurrence of paresthesia or hyporeflexia. Neurological signs and symptoms are associated with celiac disease and can be ameliorated by a gluten-free diet.

Full Text

Cited Authors

  • Cicarelli, G; Della Rocca, G; Amboni, M; Ciacci, C; Mazzacca, G; Filla, A; Barone, P

Published Date

  • December 2003

Published In

Volume / Issue

  • 24 / 5

Start / End Page

  • 311 - 317

PubMed ID

  • 14716525

Pubmed Central ID

  • 14716525

Electronic International Standard Serial Number (EISSN)

  • 1590-3478

International Standard Serial Number (ISSN)

  • 1590-1874

Digital Object Identifier (DOI)

  • 10.1007/s10072-003-0181-4


  • eng