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Consensus summary of aerosolized antimicrobial agents: application of guideline criteria. Insights from the Society of Infectious Diseases Pharmacists.

Publication ,  Journal Article
Le, J; Ashley, ED; Neuhauser, MM; Brown, J; Gentry, C; Klepser, ME; Marr, AM; Schiller, D; Schwiesow, JN; Tice, S; VandenBussche, HL; Wood, GC ...
Published in: Pharmacotherapy
June 2010

Aerosolized delivery of antimicrobial agents is an attractive option for management of pulmonary infections, as this is an ideal method of providing high local drug concentrations while minimizing systemic exposure. With the paucity of consensus regarding the safety, efficacy, and means with which to use aerosolized antimicrobials, a task force was created by the Society of Infectious Diseases Pharmacists to critically review and evaluate the literature on the use of aerosolized antiinfective agents. This article summarizes key findings and statements for preventing or treating a variety of infectious diseases, including cystic fibrosis, bronchiecstasis, hospital-acquired pneumonia, fungal infections, nontuberculosis mycobacterial infection, and Pneumocystis jiroveci pneumonia. Our intention was to provide guidance for clinicians on the use of aerosolized antibiotics through evidence-based pharmacotherapy. Further research with well-designed clinical trials is necessary to elucidate the optimal dosage and duration of therapy and, of equal importance, to appreciate the true risks associated with the use of aerosolized delivery systems.

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Published In

Pharmacotherapy

DOI

EISSN

1875-9114

Publication Date

June 2010

Volume

30

Issue

6

Start / End Page

562 / 584

Location

United States

Related Subject Headings

  • Respiratory Tract Infections
  • Pharmacology & Pharmacy
  • Patient Education as Topic
  • Nebulizers and Vaporizers
  • Humans
  • Drugs, Investigational
  • Consensus
  • Anti-Infective Agents
  • Aerosols
  • Administration, Inhalation
 

Citation

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Le, J., Ashley, E. D., Neuhauser, M. M., Brown, J., Gentry, C., Klepser, M. E., … Society of Infectious Diseases Pharmacists Aerosolized Antimicrobials Task Force, . (2010). Consensus summary of aerosolized antimicrobial agents: application of guideline criteria. Insights from the Society of Infectious Diseases Pharmacists. Pharmacotherapy, 30(6), 562–584. https://doi.org/10.1592/phco.30.6.562
Le, Jennifer, Elizabeth Dodds Ashley, Melinda M. Neuhauser, Jack Brown, Chris Gentry, Michael E. Klepser, Ann Marie Marr, et al. “Consensus summary of aerosolized antimicrobial agents: application of guideline criteria. Insights from the Society of Infectious Diseases Pharmacists.Pharmacotherapy 30, no. 6 (June 2010): 562–84. https://doi.org/10.1592/phco.30.6.562.
Le J, Ashley ED, Neuhauser MM, Brown J, Gentry C, Klepser ME, et al. Consensus summary of aerosolized antimicrobial agents: application of guideline criteria. Insights from the Society of Infectious Diseases Pharmacists. Pharmacotherapy. 2010 Jun;30(6):562–84.
Le, Jennifer, et al. “Consensus summary of aerosolized antimicrobial agents: application of guideline criteria. Insights from the Society of Infectious Diseases Pharmacists.Pharmacotherapy, vol. 30, no. 6, June 2010, pp. 562–84. Pubmed, doi:10.1592/phco.30.6.562.
Le J, Ashley ED, Neuhauser MM, Brown J, Gentry C, Klepser ME, Marr AM, Schiller D, Schwiesow JN, Tice S, VandenBussche HL, Wood GC, Society of Infectious Diseases Pharmacists Aerosolized Antimicrobials Task Force. Consensus summary of aerosolized antimicrobial agents: application of guideline criteria. Insights from the Society of Infectious Diseases Pharmacists. Pharmacotherapy. 2010 Jun;30(6):562–584.
Journal cover image

Published In

Pharmacotherapy

DOI

EISSN

1875-9114

Publication Date

June 2010

Volume

30

Issue

6

Start / End Page

562 / 584

Location

United States

Related Subject Headings

  • Respiratory Tract Infections
  • Pharmacology & Pharmacy
  • Patient Education as Topic
  • Nebulizers and Vaporizers
  • Humans
  • Drugs, Investigational
  • Consensus
  • Anti-Infective Agents
  • Aerosols
  • Administration, Inhalation