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Stereotactic radiosurgery for brain metastasis from gynecological malignancies.

Publication ,  Journal Article
Kasper, E; Ippen, F; Wong, E; Uhlmann, E; Floyd, S; Mahadevan, A
Published in: Oncol Lett
March 2017

Brain metastases are relatively uncommon in gynecological malignancies, and there is limited available data on their management. The present study reports the outcomes of patients with brain metastasis from gynecological malignancies who were treated with stereotactic radiosurgery (SRS). Patients with brain metastasis from a gynecological primary site were treated with SRS using the Cyberknife™ frameless SRS system. Primary lesions were treated with a single fraction of 16-22 Gy. A total of 3 resection cavities were treated with 8 Gy 3 times, meaning a total of 24 Gy, and 1 recurrent lesion was re-irradiated with 5 Gy 5 times, meaning a total of 25 Gy. All patients were followed up with regular magnetic resonance imaging and clinical examinations 1 month after treatment and every 2 months thereafter. A total of 20 lesions in 8 patients were included in this study; 1 patient presented with metastatic endometrial cancer and the remaining 7 presented with metastatic ovarian cancer. The median age was 61 years (range, 48-78 years). All patients had received systemic therapy prior to developing brain metastasis. A total of 3 patients underwent surgical resection and 1 patient was administered re-irradiation for recurrence. There were 3 local failures in 2 patients. The actuarial 1-, 2- and 3-year local control rates were 91, 91 and 76%, respectively. The median overall survival time was 29 months. No SRS-associated toxicities or neurological mortalities were observed. In conclusion, brain metastasis from gynecological malignancies is uncommon, however, SRS is a safe and effective treatment modality for local control as a primary or adjuvant treatment in patients with this disease.

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Published In

Oncol Lett

DOI

ISSN

1792-1074

Publication Date

March 2017

Volume

13

Issue

3

Start / End Page

1525 / 1528

Location

Greece

Related Subject Headings

  • 3211 Oncology and carcinogenesis
 

Citation

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Kasper, E., Ippen, F., Wong, E., Uhlmann, E., Floyd, S., & Mahadevan, A. (2017). Stereotactic radiosurgery for brain metastasis from gynecological malignancies. Oncol Lett, 13(3), 1525–1528. https://doi.org/10.3892/ol.2017.5621
Kasper, Ekkehard, Franziska Ippen, Eric Wong, Eric Uhlmann, Scott Floyd, and Anand Mahadevan. “Stereotactic radiosurgery for brain metastasis from gynecological malignancies.Oncol Lett 13, no. 3 (March 2017): 1525–28. https://doi.org/10.3892/ol.2017.5621.
Kasper E, Ippen F, Wong E, Uhlmann E, Floyd S, Mahadevan A. Stereotactic radiosurgery for brain metastasis from gynecological malignancies. Oncol Lett. 2017 Mar;13(3):1525–8.
Kasper, Ekkehard, et al. “Stereotactic radiosurgery for brain metastasis from gynecological malignancies.Oncol Lett, vol. 13, no. 3, Mar. 2017, pp. 1525–28. Pubmed, doi:10.3892/ol.2017.5621.
Kasper E, Ippen F, Wong E, Uhlmann E, Floyd S, Mahadevan A. Stereotactic radiosurgery for brain metastasis from gynecological malignancies. Oncol Lett. 2017 Mar;13(3):1525–1528.

Published In

Oncol Lett

DOI

ISSN

1792-1074

Publication Date

March 2017

Volume

13

Issue

3

Start / End Page

1525 / 1528

Location

Greece

Related Subject Headings

  • 3211 Oncology and carcinogenesis