Global Variations in Patient Populations and Outcomes in Heart Failure Clinical Trials.


Journal Article (Review)

PURPOSE OF REVIEW: Heart failure is a global pandemic and there has been a growing effort to enroll patients from different geographical regions in randomized controlled trials. In this review, we examined regional variation in both patient characteristics and outcomes among several of the most recent global heart failure trials RECENT FINDINGS: Retrospective analyses of global heart failure trials have identified marked variations in both baseline characteristics and management of heart failure by region of enrollment. In some trials, this variation has been significant enough to cause differential treatment effects. We summarized key heterogeneity observed in global heart failure clinical trials. Differences in both patient population and organization of these trials abroad pose an important challenge in making interpretations and country-level decisions. As such, we encourage a concerted effort to account for these differences in future research.

Full Text

Duke Authors

Cited Authors

  • Egwim, C; Dixon, B; Ambrosy, AP; Mentz, RJ

Published Date

  • February 2017

Published In

Volume / Issue

  • 14 / 1

Start / End Page

  • 30 - 39

PubMed ID

  • 28185163

Pubmed Central ID

  • 28185163

Electronic International Standard Serial Number (EISSN)

  • 1546-9549

Digital Object Identifier (DOI)

  • 10.1007/s11897-017-0316-1


  • eng

Conference Location

  • United States