Testing homogeneity of intra-run variance parameters in immunoassay.
Journal Article (Journal Article)
A common assumption in the analysis of immunoassay data is a similar pattern of within-run variation across runs of the assays. One makes this assumption without formal investigation of its validity, despite the widely acknowledged fact that accurate understanding of intra-run variation is critical to reliable calibration inference. We propose a simple procedure for a formal test of the assumption of the homogeneity of parameters that characterize intra-run variation based on representation of standard curve data from multiple assay runs by a non-linear mixed effects model. We examine the performance of the procedure and investigate the robustness of calibration inference to incorrect assumptions about the pattern of intra-run variation.
- Zeng, Q; Davidian, M
- August 15, 1997
Volume / Issue
- 16 / 15
Start / End Page
- 1765 - 1776
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)