Effectiveness of chromium in atypical depression: a placebo-controlled trial.
Journal Article
BACKGROUND: Chromium picolinate (CP) has been reported to benefit patients with symptoms of atypical depression. METHODS: A placebo-controlled, double-blind, pilot study of CP was conducted in 15 patients with DSM-IV major depressive disorder, atypical type. Patients received 600 micro g of CP or matching placebo (PBO) for 8 weeks. RESULTS: Seven (70%) CP and zero (0%) PBO patients met responder criteria (p =.02). Other outcomes were consistent with greater effect of CP. Three patients on CP failed to show any improvement. Chromium picolinate was well tolerated. CONCLUSIONS: Chromium picolinate shows promising antidepressant effects in atypical depression. Its mechanism of action may relate to 5HT2A downregulation, increased insulin sensitivity, or to other effects.
Full Text
Duke Authors
Cited Authors
- Davidson, JRT; Abraham, K; Connor, KM; McLeod, MN
Published Date
- February 1, 2003
Published In
Volume / Issue
- 53 / 3
Start / End Page
- 261 - 264
PubMed ID
- 12559660
Pubmed Central ID
- 12559660
International Standard Serial Number (ISSN)
- 0006-3223
Digital Object Identifier (DOI)
- 10.1016/s0006-3223(02)01500-7
Language
- eng
Conference Location
- United States