Effectiveness of chromium in atypical depression: a placebo-controlled trial.

Journal Article

BACKGROUND: Chromium picolinate (CP) has been reported to benefit patients with symptoms of atypical depression. METHODS: A placebo-controlled, double-blind, pilot study of CP was conducted in 15 patients with DSM-IV major depressive disorder, atypical type. Patients received 600 micro g of CP or matching placebo (PBO) for 8 weeks. RESULTS: Seven (70%) CP and zero (0%) PBO patients met responder criteria (p =.02). Other outcomes were consistent with greater effect of CP. Three patients on CP failed to show any improvement. Chromium picolinate was well tolerated. CONCLUSIONS: Chromium picolinate shows promising antidepressant effects in atypical depression. Its mechanism of action may relate to 5HT2A downregulation, increased insulin sensitivity, or to other effects.

Full Text

Duke Authors

Cited Authors

  • Davidson, JRT; Abraham, K; Connor, KM; McLeod, MN

Published Date

  • February 1, 2003

Published In

Volume / Issue

  • 53 / 3

Start / End Page

  • 261 - 264

PubMed ID

  • 12559660

Pubmed Central ID

  • 12559660

International Standard Serial Number (ISSN)

  • 0006-3223

Digital Object Identifier (DOI)

  • 10.1016/s0006-3223(02)01500-7


  • eng

Conference Location

  • United States