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Efficacy of olanzapine in social anxiety disorder: a pilot study.

Publication ,  Journal Article
Barnett, SD; Kramer, ML; Casat, CD; Connor, KM; Davidson, JRT
Published in: J Psychopharmacol
December 2002

Based on evidence suggesting anxiolytic properties of the atypical antipsychotic olanzapine, this study was conducted to evaluate whether olanzapine may be efficacious in treating social anxiety disorder (SAD). This study was an 8-week, double-blind, placebo-controlled evaluation of olanzapine as monotherapy in which 12 patients with the DSM-IV diagnosis of SAD were randomized to either olanzapine (n = 7) or placebo (n = 5). An initial dose of 5 mg/day was titrated to a maximum of 20 mg/day. Baseline to endpoint scores from the Brief Social Phobia Scale (BSPS), Social Phobia Inventory (SPIN), Liebowitz Social Anxiety Scale and Sheehan Disability Scale, as well as Clinical Global Impression-Improvement ratings, were compared for olanzapine versus placebo. Seven subjects completed all 8 weeks of the study, four in the olanzapine group and three in the placebo group. In the intent-to-treat analysis, olanzapine yielded greater improvement than placebo on the primary measures: BSPS (p = 0.02) and SPIN (p = 0.01). Both treatments were well tolerated, although the olanzapine group had more drowsiness and dry mouth. Olanzapine and placebo were both associated with negligible weight gain. Olanzapine was superior to placebo on the primary outcome measures in this preliminary study of SAD. Additional studies of olanzapine as a treatment for SAD are warranted.

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Published In

J Psychopharmacol

DOI

ISSN

0269-8811

Publication Date

December 2002

Volume

16

Issue

4

Start / End Page

365 / 368

Location

United States

Related Subject Headings

  • Psychiatry
  • Psychiatric Status Rating Scales
  • Pirenzepine
  • Pilot Projects
  • Phobic Disorders
  • Olanzapine
  • Middle Aged
  • Male
  • Humans
  • Female
 

Citation

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Barnett, S. D., Kramer, M. L., Casat, C. D., Connor, K. M., & Davidson, J. R. T. (2002). Efficacy of olanzapine in social anxiety disorder: a pilot study. J Psychopharmacol, 16(4), 365–368. https://doi.org/10.1177/026988110201600412
Barnett, Stewart D., Michelle L. Kramer, Charles D. Casat, Kathryn M. Connor, and Jonathan R. T. Davidson. “Efficacy of olanzapine in social anxiety disorder: a pilot study.J Psychopharmacol 16, no. 4 (December 2002): 365–68. https://doi.org/10.1177/026988110201600412.
Barnett SD, Kramer ML, Casat CD, Connor KM, Davidson JRT. Efficacy of olanzapine in social anxiety disorder: a pilot study. J Psychopharmacol. 2002 Dec;16(4):365–8.
Barnett, Stewart D., et al. “Efficacy of olanzapine in social anxiety disorder: a pilot study.J Psychopharmacol, vol. 16, no. 4, Dec. 2002, pp. 365–68. Pubmed, doi:10.1177/026988110201600412.
Barnett SD, Kramer ML, Casat CD, Connor KM, Davidson JRT. Efficacy of olanzapine in social anxiety disorder: a pilot study. J Psychopharmacol. 2002 Dec;16(4):365–368.
Journal cover image

Published In

J Psychopharmacol

DOI

ISSN

0269-8811

Publication Date

December 2002

Volume

16

Issue

4

Start / End Page

365 / 368

Location

United States

Related Subject Headings

  • Psychiatry
  • Psychiatric Status Rating Scales
  • Pirenzepine
  • Pilot Projects
  • Phobic Disorders
  • Olanzapine
  • Middle Aged
  • Male
  • Humans
  • Female