Predictors of treatment response in patients with posttraumatic stress disorder.

Journal Article (Clinical Trial;Journal Article;Multicenter Study)

1. This study examines the relation between baseline clinical characteristics in patients with posttraumatic stress disorder (PTSD) and response to treatment with a reversible monoamine oxidase A inhibitor (RIMA), brofaromine. 2. Data from two comparable, double-blind, placebo-controlled studies of brofaromine in patients with PTSD were combined. Bivariate analyses of variables of interest and outcome were performed. 3. Treatment response was significantly associated with lower baseline scores on the full scale Clinician-Administered PTSD Scale (CAPS) and on CAPS subscales B (re-experiencing) and C (avoidance/numbing), as well as to drug treatment with brofaromine. Placebo response was related to a history of past sexual trauma. 4. Brofaromine may have therapeutic benefit in treating PTSD, with lower baseline levels of reexperiencing and avoidance/numbing and overall less severe PTSD most predictive of outcome.

Full Text

Duke Authors

Cited Authors

  • Connor, KM; Hidalgo, RB; Crockett, B; Malik, M; Katz, RJ; Davidson, JR

Published Date

  • February 2001

Published In

Volume / Issue

  • 25 / 2

Start / End Page

  • 337 - 345

PubMed ID

  • 11294480

International Standard Serial Number (ISSN)

  • 0278-5846

Digital Object Identifier (DOI)

  • 10.1016/s0278-5846(00)00163-9


  • eng

Conference Location

  • England